Influence of county-level geographic/ancestral origin on glioma incidence and outcomes in US Hispanics.

Autor:	Walsh KM; Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.; The Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC.; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA., Neff C; Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.; Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA., Bondy ML; Department of Epidemiology and Population Health, Stanford University School of Medicine, Stanford, California, USA., Kruchko C; Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA., Huse JT; Department of Translational Molecular Pathology and Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA., Amos CI; Department of Medicine, Section of Epidemiology and Population Sciences, and Institute for Clinical and Translational Research, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, Texas, USA., Barnholtz-Sloan JS; Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.; Center for Biomedical Informatics & Information Technology and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland, USA., Ostrom QT; Department of Neurosurgery, Duke University School of Medicine, Durham, North Carolina, USA.; The Preston Robert Tisch Brain Tumor Center, Duke University School of Medicine, Durham, NC.; Duke Cancer Institute, Duke University Medical Center, Durham, North Carolina, USA.; Central Brain Tumor Registry of the United States, Hinsdale, Illinois, USA.
Jazyk:	angličtina
Zdroj:	Neuro-oncology [Neuro Oncol] 2023 Feb 14; Vol. 25 (2), pp. 398-406.
DOI:	10.1093/neuonc/noac175
Abstrakt:	Background: Glioma incidence is 25% lower in Hispanics than White non-Hispanics. The US Hispanic population is diverse, and registry-based analyses may mask incidence differences associated with geographic/ancestral origins. Methods: County-level glioma incidence data in Hispanics were retrieved from the Central Brain Tumor Registry of the United States. American Community Survey data were used to determine the county-level proportion of the Hispanic population of Mexican/Central American and Caribbean origins. Age-adjusted incidence rate ratios and incidence rate ratios (IRRs) quantified the glioma incidence differences across groups. State-level estimates of admixture in Hispanics were obtained from published 23andMe data. Results: Compared to predominantly Caribbean-origin counties, predominantly Mexican/Central American-origin counties had lower age-adjusted risks of glioma (IRR = 0.83; P < 0.0001), glioblastoma (IRR = 0.86; P < 0.0001), diffuse/anaplastic astrocytoma (IRR = 0.78; P < 0.0001), oligodendroglioma (IRR = 0.82; P < 0.0001), ependymoma (IRR = 0.88; P = 0.012), and pilocytic astrocytoma (IRR = 0.76; P < 0.0001). Associations were consistent in children and adults and using more granular geographic regions. Despite having lower glioma incidence, Hispanic glioblastoma patients from predominantly Mexican/Central American-origin counties had poorer survival than Hispanics living in predominantly Caribbean-origin counties. Incidence and survival differences could be partially explained by state-level estimates of European admixture in Hispanics with European admixture associated with higher incidence and improved survival. Conclusions: Glioma incidence and outcomes differ in association with the geographic origins of Hispanic communities, with counties of predominantly Mexican/Central American origin at significantly reduced risk and those of Caribbean origin at comparatively greater risk. Although typically classified as a single ethnic group, appreciating the cultural, socioeconomic, and genetic diversity of Hispanics can advance cancer disparities research. (Published by Oxford University Press on behalf of the Society for Neuro-Oncology 2022.)
Databáze:	MEDLINE
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