Vitamin D 25OH Deficiency and Mortality in Moderate to Severe COVID-19: A Multi-Center Prospective Observational Study.

Autor:	Bogliolo L; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Cereda E; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Klersy C; Clinical Epidemiology & Biostatistics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Stefano L; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Lobascio F; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Masi S; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Crotti S; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Bugatti S; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Montecucco C; Division of Rheumatology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy., Demontis S; Nutritional Unit, Giovanni Borea Civil Hospital, Sanremo, Italy., Mascheroni A; Clinical Nutrition and Dietetics Unit-ASST Melegnano e Martesana, Melegnano (Milano), Italy., Cerutti N; Medicine and Dietetics Unit, ASST Pavia, Pavia, Italy., Malesci A; Division of Gastroenterology and Digestive Endoscopy, Department of Gastroenterology, Humanitas Research Hospital, Milano, Italy., Corrao S; Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.; COVID Unit, Department of Internal Medicine, National Relevance and High Specialization Hospital Trust ARNAS Civico, Di Cristina, Benfratelli, Palermo, Italy., Caccialanza R; Clinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Jazyk:	angličtina
Zdroj:	Frontiers in nutrition [Front Nutr] 2022 Jul 05; Vol. 9, pp. 934258. Date of Electronic Publication: 2022 Jul 05 (Print Publication: 2022).
DOI:	10.3389/fnut.2022.934258
Abstrakt:	Introduction: Several studies and meta-analyses suggested the role of vitamin D 25OH in preventing severe forms of coronavirus disease 2019 (COVID-19). However, the evidence on the clinical benefits of vitamin D 25OH adequacy in patients hospitalized for COVID-19 remain conflicting and speculative. We aimed to investigate the association between vitamin D 25OH serum levels and mortality in hospitalized patients with moderate to severe COVID-19. Method: This prospective observational multicentre study included 361 consecutive patients with moderate to severe COVID-19 admitted to the Italian hospitals involved in the NUTRI-COVID19 trial from March to August 2020. For each patient, serum vitamin D 25OH levels were assessed 48 h since admission and classified as deficient (<20 ng/mL) or adequate (≥20 ng/mL). We built a propensity score for low/adequate vitamin D 25OH levels to balance the clinical and demographic properties of the cohort, which resulted in 261 patients with good common support used for the survival analysis. Results: Two Hundred-seventy-seven (77%) of the 361 enrolled patients (207 [57%] males, median age 73 ± 15.6 years) had vitamin D 25OH deficiency. Fifty-two (20%) of the 261 matched patients died during the hospital stay, corresponding to a hazard ratio of 1.18 for vitamin D 25OH deficiency (95% confidence interval: 0.86-1.62; p = 0.29). Discussion: The prevalence of vitamin D 25OH deficiency was confirmed to be very high in hospitalized patients with COVID-19. The use of a propensity score demonstrate an absence of significant association between vitamin D deficiency and mortality in hospitalized patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Bogliolo, Cereda, Klersy, Stefano, Lobascio, Masi, Crotti, Bugatti, Montecucco, Demontis, Mascheroni, Cerutti, Malesci, Corrao, Caccialanza and the NUTRI-COVID19 Collaborative Working Group.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu