Combating small molecule environmental contaminants: detection and sequestration using functional nucleic acids.
| Autor: | Sanford AA; Department of Chemistry, Emory University Atlanta Georgia 30322 USA jen.heemstra@emory.edu., Manuel BA; Department of Chemistry, Emory University Atlanta Georgia 30322 USA jen.heemstra@emory.edu., Romero-Reyes MA; Department of Chemistry, Emory University Atlanta Georgia 30322 USA jen.heemstra@emory.edu.; Department of Chemistry, Hanover College Hanover Indiana 47243 USA romeroreyes@hanover.edu., Heemstra JM; Department of Chemistry, Emory University Atlanta Georgia 30322 USA jen.heemstra@emory.edu.; Department of Biomedical Engineering, Georgia Institute of Technology, Emory University Atlanta GA 30332 USA. |
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| Jazyk: | angličtina |
| Zdroj: | Chemical science [Chem Sci] 2022 Jun 06; Vol. 13 (26), pp. 7670-7684. Date of Electronic Publication: 2022 Jun 06 (Print Publication: 2022). |
| DOI: | 10.1039/d2sc00117a |
| Abstrakt: | Small molecule contaminants pose a significant threat to the environment and human health. While regulations are in place for allowed limits in many countries, detection and remediation of contaminants in more resource-limited settings and everyday environmental sources remains a challenge. Functional nucleic acids, including aptamers and DNA enzymes, have emerged as powerful options for addressing this challenge due to their ability to non-covalently interact with small molecule targets. The goal of this perspective is to outline recent efforts toward the selection of aptamers for small molecules and describe their subsequent implementation for environmental applications. Finally, we provide an outlook that addresses barriers that hinder these technologies from being widely adopted in field friendly settings and propose a path forward toward addressing these challenges. Competing Interests: There are no conflicts to declare. (This journal is © The Royal Society of Chemistry.) |
| Databáze: | MEDLINE |
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