Cancers and Benign Processes on 68 Ga PSMA PET-CT Imaging Other than Prostate Cancer.

Autor: Ozcan PP; Department of Nuclear Medicine, Mersin University, Faculty of Medicine, Mersin, Turkey., Serdengectı M; Department of Nuclear Medicine, Aksaray University, Faculty of Medicine, Aksaray, Turkey., Koc ZP; Department of Nuclear Medicine, Mersin University, Faculty of Medicine, Mersin, Turkey., Balcı Y; Department of Radiology, Mersin University, Faculty of Medicine, Mersin, Turkey., Tek M; Department of Urology, Mersin University, Faculty of Medicine, Mersin, Turkey., Bozlu M; Department of Urology, Mersin University, Faculty of Medicine, Mersin, Turkey., Akbay E; Department of Urology, Mersin University, Faculty of Medicine, Mersin, Turkey., Erçolak V; Department of Oncology, Mersin University, Faculty of Medicine, Mersin, Turkey.
Jazyk: angličtina
Zdroj: World journal of nuclear medicine [World J Nucl Med] 2022 Jul 05; Vol. 21 (2), pp. 106-111. Date of Electronic Publication: 2022 Jul 05 (Print Publication: 2022).
DOI: 10.1055/s-0042-1750331
Abstrakt: Background  Imaging plays an important role in the evaluation of prostate cancer patients. In recent years, much attention has been focused on gallium 68 prostate-specific membrane antigen positron emission tomography-computed tomography ( 68 Ga PSMA PET-CT) in prostate cancer patients and has been widely used for staging, restaging, and therapy response for these patients. The aim of this study was to report 68 Ga PSMA PET-CT in other cancers and benign processes incidentally detected on 68 Ga PSMA PET-CT in patients with prostate cancer. Materials and Methods  A total of 600 68 Ga PSMA PET-CT scans were performed for initial staging, restaging, detection of suspected recurrence, and therapy response in prostate cancer patients between December 2018 and June 2020. A total of 38 patients with histopathologically proven prostate cancer were included in the current study with other malignancies and benign processes. Mainly histopathology in most of cases and clinical and radiological follow-up in few cases after PET/CT scanning served as the standard of reference. Results  A total of 38 patients (age range: 52-85 years; mean age: 68.6) with prostate cancer final histopathology results were included in the study. A total of 51 lesion sites were evaluated in 38 patients. Forty-one lesion regions of these 51 regions were based on histopathological diagnosis, whereas 10 of them were based on clinical follow-up and conventional radiological follow-up as differential criteria. Thirty of 51 lesion regions were evaluated as malignant and 21 were benign lesions. The most common 68 Ga PSMA ligand avid malignancy was lung adenocarcinoma (6/38). Conclusions  Prostate-specific membrane antigen (PSMA) is a cell surface glycoprotein and mainly expressed in prostate epithelium. 68 Ga PSMA PET-CT imaging is very sensitive and specific imaging modality in prostate cancer patients. However, other malignancies and some benign processes may also have 68 Ga PSMA ligand avidity and some prostate cancer metastases may imitate other malignancies.
Competing Interests: Conflict of Interest None declared.
(World Association of Radiopharmaceutical and Molecular Therapy (WARMTH). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
Databáze: MEDLINE
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