Oral microbiota signatures in post-traumatic stress disorder (PTSD) veterans.

Autor: Levert-Levitt E; School of Psychological Sciences, Center for the Study of Child Development, University of Haifa, 6035 Rabin Building, Haifa, 3190501, Israel., Shapira G; Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Sagol School of Neuroscience, Edmond J Safra Center for Bioinformatics, Tel Aviv University, Tel Aviv, 69978, Israel., Sragovich S; Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, 69978, Tel Aviv, Israel., Shomron N; Department of Cell and Developmental Biology, Sackler Faculty of Medicine, Sagol School of Neuroscience, Edmond J Safra Center for Bioinformatics, Tel Aviv University, Tel Aviv, 69978, Israel., Lam JCK; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China., Li VOK; Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong, China., Heimesaat MM; Institute for Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany., Bereswill S; Institute for Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, Hindenburgdamm 30, 12203, Berlin, Germany., Yehuda AB; Department of Health and Well-being, Medical Corps, Israel Defense Forces (IDF), Ramat Gan, Israel.; 'Shalvata' Mental Health Center, Clalit Health Services, Hod Hasharon, 4534708, Israel., Sagi-Schwartz A; School of Psychological Sciences, Center for the Study of Child Development, University of Haifa, 6035 Rabin Building, Haifa, 3190501, Israel., Solomon Z; Gershon H. Gordon Faculty of Social Sciences, Tel Aviv University, Tel Aviv, 69978, Israel., Gozes I; Elton Laboratory for Molecular Neuroendocrinology, Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Adams Super Center for Brain Studies and Sagol School of Neuroscience, Tel Aviv University, 69978, Tel Aviv, Israel. igozes@tauex.tau.ac.il.
Jazyk: angličtina
Zdroj: Molecular psychiatry [Mol Psychiatry] 2022 Nov; Vol. 27 (11), pp. 4590-4598. Date of Electronic Publication: 2022 Jul 22.
DOI: 10.1038/s41380-022-01704-6
Abstrakt: Post-traumatic stress disorder (PTSD) represents a global public health concern, affecting about 1 in 20 individuals. The symptoms of PTSD include intrusiveness (involuntary nightmares or flashbacks), avoidance of traumatic memories, negative alterations in cognition and mood (such as negative beliefs about oneself or social detachment), increased arousal and reactivity with irritable reckless behavior, concentration problems, and sleep disturbances. PTSD is also highly comorbid with anxiety, depression, and substance abuse. To advance the field from subjective, self-reported psychological measurements to objective molecular biomarkers while considering environmental influences, we examined a unique cohort of Israeli veterans who participated in the 1982 Lebanon war. Non-invasive oral 16S RNA sequencing was correlated with psychological phenotyping. Thus, a microbiota signature (i.e., decreased levels of the bacteria sp_HMT_914, 332 and 871 and Noxia) was correlated with PTSD severity, as exemplified by intrusiveness, arousal, and reactivity, as well as additional psychopathological symptoms, including anxiety, hostility, memory difficulties, and idiopathic pain. In contrast, education duration correlated with significantly increased levels of sp_HMT_871 and decreased levels of Bacteroidetes and Firmicutes, and presented an inverted correlation with adverse psychopathological measures. Air pollution was positively correlated with PTSD symptoms, psychopathological symptoms, and microbiota composition. Arousal and reactivity symptoms were correlated with reductions in transaldolase, an enzyme controlling a major cellular energy pathway, that potentially accelerates aging. In conclusion, the newly discovered bacterial signature, whether an outcome or a consequence of PTSD, could allow for objective soldier deployment and stratification according to decreases in sp_HMT_914, 332, 871, and Noxia levels, coupled with increases in Bacteroidetes levels. These findings also raise the possibility of microbiota pathway-related non-intrusive treatments for PTSD.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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