Gene expression patterns in Atlantic salmon (Salmo salar) with severe nephrocalcinosis.

Autor: Klykken C; Aqua Kompetanse AS, Flatanger, Norway.; Department of Biology, Faculty of Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway., Boissonnot L; Aqua Kompetanse AS, Flatanger, Norway., Reed AK; Pharmaq Analytiq AS, Bergen, Norway., Whatmore P; eResearch Department, Queensland Univesity of Technology, Brisbane, QLD, Australia., Attramadal K; Department of Biotechnology and Food Science, Faculty of Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway., Olsen RE; Department of Biology, Faculty of Science and Technology, Norwegian University of Science and Technology, Trondheim, Norway.
Jazyk: angličtina
Zdroj: Journal of fish diseases [J Fish Dis] 2022 Nov; Vol. 45 (11), pp. 1645-1658. Date of Electronic Publication: 2022 Jul 21.
DOI: 10.1111/jfd.13687
Abstrakt: Nephrocalcinosis is a common disorder in farmed Atlantic salmon, but the consequences for the fish physiology are not well understood. We performed a transcriptome study in kidneys of Atlantic salmon (Salmo salar) smolts without and with severe chronic nephrocalcinosis (NC). The study revealed that numerous genes are differentially expressed in fish with NC compared with healthy salmon. The most evident changes in gene expression patterns in the NC group were a massive downregulation of metabolism and energy production, upregulation of signalling pathways important for tissue repair and function maintenance and upregulation of inflammatory responses. Overall, the extensive tissue damage and the gene regulation responses that affect salmon with severe nephrocalcinosis are highly likely to have dramatic consequences on fish survival.
(© 2022 The Authors. Journal of Fish Diseases published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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