Exploring the role of antibiotics and steroids in managing respiratory diseases.

Autor: Chellappan DK; Department of Life Sciences, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia., Prasher P; Department of Chemistry, University of Petroleum and Energy Studies, Dehradun, India., Shukla SD; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, New South Wales, Australia.; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia., Yee TW; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia., Kah TK; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia., Xyan TW; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia., Kid TW; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia., Si TH; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia., Weng TS; School of Pharmacy, International Medical University, Kuala Lumpur, Malaysia., Molugulu N; School of Pharmacy, Monash University Malaysia, Subang Jaya, Selangor, Malaysia., Sakthivel LP; Department of Pharmaceutical Technology, University College of Engineering (BIT Campus), Anna University, Tiruchirappalli, India., Chellian J; Department of Life Sciences, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia., Madheswaran T; Department of Pharmaceutical Technology, International Medical University, Kuala Lumpur, Malaysia., Malipeddi H; Department of Chemistry, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu, India., Singh Y; Department of Pharmacology, Maharishi Arvind College of Pharmacy, Jaipur, Rajasthan, India., Dureja H; Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India., Kapoor DN; Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India., Negi P; Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India., Goyal R; Department of Pharmacology, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India., Thangavelu L; Department of Pharmacology, Saveetha Dental College, Saveetha University, Chennai, India., Kumar D; Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India., Gupta PK; Department of Life Sciences, School of Basic Sciences and Research, Sharda University, Greater Noida, Uttar Pradesh, India., Jha NK; Department of Biotechnology, School of Engineering & Technology (SET), Sharda University, Greater Noida, Uttar Pradesh, India., Shastri MD; School of Pharmacy and Pharmacology, University of Tasmania, Hobart, Australia., MacLoughlin R; Research and Development, Science and Emerging Technologies, Aerogen Limited, Galway, Ireland.; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.; School of Pharmacy and Pharmaceutical Sciences, Trinity College, Dublin, Ireland., Singh SK; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Gulati M; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.; School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India., Gupta G; School of Pharmacy, Suresh Gyan Vihar University, Jaipur, India.; Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.; Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India., Dua K; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Ultimo, New South Wales, Australia.; Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, Australia.; Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, India.
Jazyk: angličtina
Zdroj: Journal of biochemical and molecular toxicology [J Biochem Mol Toxicol] 2022 Oct; Vol. 36 (10), pp. e23174. Date of Electronic Publication: 2022 Jul 21.
DOI: 10.1002/jbt.23174
Abstrakt: Respiratory diseases (RDs), such as chronic obstructive pulmonary disease, cystic fibrosis, asthma, and pneumonia, are associated with significant morbidity and mortality. Treatment usually consists of antibiotics and steroids. Relevant published literature reviews, studies, and clinical trials were accessed from institutional and electronic databases. The keywords used were respiratory diseases, steroids, antibiotics, and combination of steroids and antibiotics. Selected articles and literature were carefully reviewed. Antibiotics are often prescribed as the standard therapy to manage RDs. Types of causative respiratory pathogens, spectrum of antibiotics activity, route of administration, and course of therapy determine the type of antibiotics that are prescribed. Despite being associated with good clinical outcome, treatment failure and recurrence rate are still high. In addition, antibiotic resistance has been widely reported due to bacterial mutations in response to the use of antibiotics, which render them ineffective. Nevertheless, there has been a growing demand for corticosteroids (CS) and antibiotics to treat a wide variety of diseases, including various airway diseases, due to their immunosuppressive and anti-inflammatory properties. The use of CS is well established and there are different formulations based on the diseases, such as topical administration, tablets, intravenous injections, and inhaled preparations. Both antibiotics and CS possess similar properties in terms of their anti-inflammatory effects, especially regulating cytokine release. Thus, the current review examines and discusses the different applications of antibiotics, CS, and their combination in managing various RDs. Drawbacks of these interventions are also discussed.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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