Using large databases to study cancer genomics in an undergraduate classroom.

Autor: Melloy PG; Department of Biological Sciences, Fairleigh Dickinson University, Madison, New Jersey, USA., Chiswell B; NYSCAS, Touro College, New York, New York, USA., Peterson C; Department of Biology, Suffolk University, Boston, Massachusetts, United States.
Jazyk: angličtina
Zdroj: Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology [Biochem Mol Biol Educ] 2022 Sep; Vol. 50 (5), pp. 460-462. Date of Electronic Publication: 2022 Jul 21.
DOI: 10.1002/bmb.21651
Abstrakt: Cancer databases collect original cancer studies and patient clinical information into one site that allows for global analysis. While many courses focus on cancer, few utilize these powerful cancer databases. Our goal was to create a lab experience in which students could explore original cancer study databases, looking at the expression and incidence of driver mutations of cancer. First, the students focus on a specific patient including demographic data and type of cancer. Then the students analyze mRNA expression levels associated with mutations of the gene, determining if it is a tumor suppressor or oncogene. Students also learn which mutations are actionable and how they affect survival. In summary, this module allows students to analyze global trends in driver mutations in cancers and dive into specific patient features.
(© 2022 International Union of Biochemistry and Molecular Biology.)
Databáze: MEDLINE
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