Genome Sequencing Variations in the Octodon degus , an Unconventional Natural Model of Aging and Alzheimer's Disease.

Autor:	Hurley MJ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom.; Department of Ecological Sciences, Faculty of Sciences, Institute of Ecology and Biodiversity, Universidad de Chile, Santiago, Chile., Urra C; Department of Ecological Sciences, Faculty of Sciences, Institute of Ecology and Biodiversity, Universidad de Chile, Santiago, Chile., Garduno BM; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA, United States., Bruno A; Department of Food and Drug, University of Parma, Parma, Italy., Kimbell A; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, United States., Wilkinson B; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, United States., Marino-Buslje C; Bioinformatics Unit, Leloir Institute Foundation (FIL), Buenos Aires, Argentina., Ezquer M; Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile., Ezquer F; Centro de Medicina Regenerativa, Facultad de Medicina, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile., Aburto PF; Department of Ecological Sciences, Faculty of Sciences, Institute of Ecology and Biodiversity, Universidad de Chile, Santiago, Chile., Poulin E; Department of Ecological Sciences, Faculty of Sciences, Institute of Ecology and Biodiversity, Universidad de Chile, Santiago, Chile., Vasquez RA; Department of Ecological Sciences, Faculty of Sciences, Institute of Ecology and Biodiversity, Universidad de Chile, Santiago, Chile., Deacon R; Department of Ecological Sciences, Faculty of Sciences, Institute of Ecology and Biodiversity, Universidad de Chile, Santiago, Chile., Avila A; Biomedical Sciences Research Laboratory, Faculty of Medicine, Universidad Católica de la Santísima Concepción, Concepción, Chile., Altimiras F; Faculty of Engineering and Business, Universidad de las Americas, Santiago, Chile., Whitney Vanderklish P; Department Molecular Medicine, Scripps Research, La Jolla, CA, United States., Zampieri G; School of Computing, Engineering and Digital Technologies, Teesside University, Middlesbrough, United Kingdom., Angione C; School of Computing, Engineering and Digital Technologies, Teesside University, Middlesbrough, United Kingdom., Constantino G; Department of Food and Drug, University of Parma, Parma, Italy., Holmes TC; Department Physiology & Biophysics, School of Medicine, University of California, Irvine, Irvine, CA, United States., Coba MP; Zilkha Neurogenetic Institute, University of Southern California, Los Angeles, CA, United States.; Department of Psychiatry and Behavioral Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States., Xu X; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA, United States., Cogram P; Department of Ecological Sciences, Faculty of Sciences, Institute of Ecology and Biodiversity, Universidad de Chile, Santiago, Chile.; Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in aging neuroscience [Front Aging Neurosci] 2022 Jun 30; Vol. 14, pp. 894994. Date of Electronic Publication: 2022 Jun 30 (Print Publication: 2022).
DOI:	10.3389/fnagi.2022.894994
Abstrakt:	The degu ( Octodon degus ) is a diurnal long-lived rodent that can spontaneously develop molecular and behavioral changes that mirror those seen in human aging. With age some degu, but not all individuals, develop cognitive decline and brain pathology like that observed in Alzheimer's disease including neuroinflammation, hyperphosphorylated tau and amyloid plaques, together with other co-morbidities associated with aging such as macular degeneration, cataracts, alterations in circadian rhythm, diabetes and atherosclerosis. Here we report the whole-genome sequencing and analysis of the degu genome, which revealed unique features and molecular adaptations consistent with aging and Alzheimer's disease. We identified single nucleotide polymorphisms in genes associated with Alzheimer's disease including a novel apolipoprotein E ( Apoe ) gene variant that correlated with an increase in amyloid plaques in brain and modified the in silico predicted degu APOE protein structure and functionality. The reported genome of an unconventional long-lived animal model of aging and Alzheimer's disease offers the opportunity for understanding molecular pathways involved in aging and should help advance biomedical research into treatments for Alzheimer's disease. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Hurley, Urra, Garduno, Bruno, Kimbell, Wilkinson, Marino-Buslje, Ezquer, Ezquer, Aburto, Poulin, Vasquez, Deacon, Avila, Altimiras, Whitney Vanderklish, Zampieri, Angione, Constantino, Holmes, Coba, Xu and Cogram.)
Databáze:	MEDLINE
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