Hydroalcoholic Extract of Sechium edule Fruits Attenuates QT Prolongation in High Fat Diet-Induced Hyperlipidemic Mice.

Autor: Mohammed FS; Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal, India., Ghosh A; Department of Pharmaceutical Sciences, Jharkhand Rai University, Ratu Rd, Kamre, Ranchi 835222, Jharkhand, India., Pal S; Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal, India., Das C; Department of Pharmacology, Calcutta Institute of Pharmaceutical Technology & AHS, Uluberia, Howrah 711316, West Bengal, India., Alomar SY; Department of Zoology, College of Science, King Saud University, Riyadh-11451, Saudi Arabia., Patwekar M; Luqman College of Pharmacy, Gulbarga, Karnataka, India., Patwekar F; Luqman College of Pharmacy, Gulbarga, Karnataka, India., Jeon BH; Department of Earth Resources & Environmental Engineering, Hanyang University, 222-Wangsimni-ro, Seongdong-gu, Seoul 04763, Republic of Korea., Islam F; Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka 1207, Bangladesh.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2022 Jul 11; Vol. 2022, pp. 8682316. Date of Electronic Publication: 2022 Jul 11 (Print Publication: 2022).
DOI: 10.1155/2022/8682316
Abstrakt: The present study aimed to evaluate the effect of hydroalcoholic extract of Sechium edule (S.E.) fruits on lipid profile and electrocardiogram (ECG) parameters in high fat-diet (HFD) induced hyperlipidemic mice. In this study, grouping of animals was done as described below ( n  = 6), where group 1 is normal control, group 2 is HFD control, group 3 is HFD + atorvastatin (10 mg/kg), group 4 is HFD + S.E. extract (200 mg/kg), and group 5 is HFD + S.E. extract (400 mg/kg). The first 3 weeks animals were supplemented with HFD, and the last 3 weeks animals were supplemented with HFD along with atorvastatin (10 mg/kg) or S.E. extract (200 and 400 mg/kg). It was observed that mice of the HFD control group showed a significant rise in the total cholesterol, triglycerides, LDL-C, and VLDL-C levels and a notable decrease in HDL-C levels. In addition, a consequential increment in ECG parameters such as QT or QTc and RR interval and a noteworthy decline in the heart rate were observed in HFD control mice. Treatment with S.E. extract (200 and 400 mg/kg) showed a significant improvement in the lipid profile. Moreover, the extract also significantly normalized the prolonged QT or QTc and RR interval and the heart rate in HFD-challenged mice. Hence, we can conclude that S.E. extract encumbers the prolongation of QT or QTc and RR interval and increased the heart rate in HFD-challenged mice.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2022 Firdous Sayed Mohammed et al.)
Databáze: MEDLINE
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