Late-Onset Leber's Hereditary Optic Neuropathy with Concurrent Retinal Detachment and Retrobulbar Visual Pathway Involvement.

Autor: Zhang X; Department of Neurology, University of Illinois College of Medicine Peoria, Peoria, Illinois, USA., Meagher S; Department of Radiology, University of Illinois College of Medicine Peoria, Peoria, Illinois, USA., Han MK; Illinois Eye Institute, Peoria, Illinois, USA., Kattah J; Department of Neurology, University of Illinois College of Medicine Peoria, Peoria, Illinois, USA.
Jazyk: angličtina
Zdroj: Neuro-ophthalmology (Aeolus Press) [Neuroophthalmology] 2021 Dec 22; Vol. 46 (4), pp. 248-253. Date of Electronic Publication: 2021 Dec 22 (Print Publication: 2022).
DOI: 10.1080/01658107.2021.2006239
Abstrakt: We report a case of late-onset Leber's hereditary optic neuropathy (LHON) with concurrent retinal detachment, mild retinal pigment epithelial changes, cataract and hyperintensity on fluid-attenuated inversion recovery magnetic resonance imaging affecting the entire retrobulbar visual pathway. We also documented that progression of the visual field defect correlated with retinal nerve fibre layer and ganglion cell layer-inner plexiform layer changes on optical coherence tomography. Our case provides further understanding of LHON as a disorder of the entire pre-geniculate pathways and also highlights that detailed history taking in addition to recognition of typical sequential optic disc appearance and visual field characteristics at different stages of LHON remain critical even in this era of modern imaging, autoimmune biomarkers and genetic testing.
Competing Interests: No potential conflict of interest was reported by the authors.
(© 2021 Taylor & Francis Group, LLC.)
Databáze: MEDLINE
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