Role of calcium metabolism in ADHD: The relationship between parathyroid hormone and ADHD symptom severity.

Autor: Altun Varmiş D; Department of Child and Adolescent Psychiatry, Adana Ekrem Tok Mental Health Hospital, Adana, Turkey., Yapça Kaypakli G; Department of Child and Adolescent Psychiatry, Hatay State Hospital, Hatay, Turkey., Yolga Tahiroğlu A; Department of Child and Adolescent Psychiatry, Cukurova University, Faculty of Medicine, Adana, Turkey., Avci A; Department of Child and Adolescent Psychiatry, Cukurova University, Faculty of Medicine, Adana, Turkey., Gül Çelik G; Department of Child and Adolescent Psychiatry, Cukurova University, Faculty of Medicine, Adana, Turkey., Metin Ö; Department of Child and Adolescent Psychiatry, Cukurova University, Faculty of Medicine, Adana, Turkey., Matyar S; Department of Biochemistry, Cukurova University, Faculty of Medicine, Adana, Turkey., Öztürk ÖG; Department of Biochemistry, Cukurova University, Faculty of Medicine, Adana, Turkey.
Jazyk: angličtina
Zdroj: Indian journal of psychiatry [Indian J Psychiatry] 2022 May-Jun; Vol. 64 (3), pp. 257-263. Date of Electronic Publication: 2022 Jun 08.
DOI: 10.4103/indianjpsychiatry.indianjpsychiatry_484_21
Abstrakt: Background: Vitamin D has been found to be associated with the pathogenesis of attention deficit hyperactivity disorder (ADHD). However, the potential role of parathyroid hormone (PTH) is still unclear.
Aim: We aimed to investigate the association between calcium metabolism and ADHD symptomatology.
Methods: We included 106 participants aged between 7 and 13 years old (51 ADHD patients, mean age: 9.54 ± 1.77, 55 healthy controls mean age: 9.97 ± 0.94) to this study. K-SADS-PL and Conners' Parent/Teacher Rating Scales, Stroop Test were performed. Blood samples to measure serum levels of Vitamin D, PTH, calcium (Ca), magnesium (Mg), phosphorus (P), and alkaline phosphatase (ALP) were collected in the spring (March-April-May) to prevent seasonal variability.
Results: PTH, P, and ALP values were significantly lower and Vitamin D, Ca, and Mg values were significantly higher in the ADHD group ( P < 0.05, for all). Both groups had Vitamin D deficiency. Control group has lower Vitamin D levels than the ADHD group (respectively; 17.66 ± 9.07, 21.99 ± 10.99, P < 0.05). There was a negative correlation between PTH and CTRS hyperactivity, CGI-RI and CGI-EL sub-scores, CGI-Total, DSM-IV-Inattention, DSM-IV Hyperactivity/Impulsivity, DSM-IV-Total scores ( P < 0.05, for all).
Conclusions: We found lower PTH levels in ADHD patients and a strong and negative correlation between PTH and symptom severity. Future studies are needed to clarify if these findings are due to the key role of PTH in ADHD pathology or PTH's function in activating vitamin D.
Competing Interests: There are no conflicts of interest.
(Copyright: © 2022 Indian Journal of Psychiatry.)
Databáze: MEDLINE