Effects of Sex, APOE4, and Lifestyle Activities on Cognitive Reserve in Older Adults.

Autor:	Pa J; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor. judypa@usc.edu., Aslanyan V; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Casaletto KB; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Rentería MA; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Harrati A; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Tom SE; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Armstrong N; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Rajan K; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Avila-Rieger J; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Gu Y; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Schupf N; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Manly JJ; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Brickman A; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor., Zahodne L; From the Alzheimer's Disease Cooperative Study (J.P.), Department of Neurosciences, School of Medicine, UCSD Health, San Diego, CA; Mark and Mary Stevens Neuroimaging and Informatics Institute (J.P., V.A.), USC Alzheimer Disease Research Center, Department of Neurology, University of Southern California, Los Angeles; Department of Population and Public Health Sciences (V.A.), Keck School of Medicine, University of Southern California, Los Angeles; Memory and Aging Center (K.B.C.), Department of Neurology, University of California, San Francisco; Taub Institute for Research on Alzheimer's Disease and the Aging Brain (M.A.R., J.A.-R., Y.G., N.S., J.J.M., A.B.), Department of Neurology, Columbia University, New York City; Center for Population Health Sciences (A.H.), Department of Primary Care and Population Health, Stanford University, CA; Department of Neurology (S.E.T.), Vagelos College of Physicians and Surgeons and Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City; Laboratory of Behavioral Neuroscience (N.A.), National Institute on Aging, Bethesda, MD; Department of Psychiatry and Human Behavior (N.A.), Warren Alpert Medical School of Brown University, Providence, RI; Department of Public Health Sciences (K.R.), University of California, Davis; and Department of Psychology (L.Z.), University of Michigan, Ann Arbor.
Jazyk:	angličtina
Zdroj:	Neurology [Neurology] 2022 Aug 23; Vol. 99 (8), pp. e789-e798. Date of Electronic Publication: 2022 Jul 20.
DOI:	10.1212/WNL.0000000000200675
Abstrakt:	Background and Objectives: Lifestyle activities, such as physical activity and cognitive stimulation, may mitigate age-associated cognitive decline, delay dementia onset, and increase cognitive reserve. Whether the association between lifestyle activities and cognitive reserve differs by sex and APOE4 status is an understudied yet critical component for informing targeted prevention strategies. The current study examined interactions between sex and physical or cognitive activities on cognitive reserve for speed and memory in older adults. Methods: Research participants with unimpaired cognition, mild cognitive impairment, or dementia from the Washington Heights-Inwood Columbia Aging Cohort were included in this study. Cognitive reserve scores for speed and memory were calculated by regressing out hippocampal volume, total gray matter volume, and white matter hyperintensity volume from composite cognitive scores for speed and memory, respectively. Self-reported physical activity was assessed using the Godin Leisure Time Exercise Questionnaire, converted to metabolic equivalents (METS). Self-reported cognitive activity (COGACT) was calculated as the sum of 3 yes/no questions. Sex by activity interactions and sex-stratified analyses were conducted using multivariable linear regression models, including a secondary analysis with APOE4 as a moderating factor. Results: Seven hundred fifty-eight participants (mean age = 76.11 ± 6.31 years, 62% women) were included in this study. Higher METS was associated with greater speed reserve in women (β = 0.04, CI 0.0-08) but not in men (β = 0.004, CI -0.04 to 0.05). METS was not associated with memory reserve in women or men. More COGACT was associated with greater speed reserve in the cohort (β = 0.13, CI 0.05-0.21). More COGACT had a trend for greater memory reserve in women (β = 0.06, CI -0.02 to 0.14) but not in men (β = -0.04, CI -0.16 to 0.08). Only among women, APOE4 carrier status attenuated relationships between METS and speed reserve (β = -0.09, CI -0.22 to 0.04) and between COGACT and both speed (β = -0.26, CI -0.63 to 0.11) and memory reserves (β = -0.20, CI -0.50.0 to 093). Discussion: The associations of self-reported physical and cognitive activities with cognitive reserve are more pronounced in women, although APOE4 attenuates these associations. Future studies are needed to understand the causal relationship among sex, lifestyle activities, and genetic factors on cognitive reserve in older adults to best understand which lifestyle activities may be most beneficial and for whom. (Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.)
Databáze:	MEDLINE
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