Silver Trimolybdate (Ag 2 Mo 3 O 10 .2H 2 O) Nanorods: Synthesis, Characterization, and Photo-Induced Antibacterial Activity under Visible-Light Irradiation.

Autor: do Nascimento Silva Leandro MK; Laboratório de Microbiologia e Biologia Molecular-LMBM, Universidade Regional do Cariri-URCA, Crato, Ceará, Brazil.; Centro Universitário Dr. Leão Sampaio-Unileão Juazeiro do Norte, Juazeiro do Norte, Ceará, Brazil., Barbosa Moura JV; Departamento de Física, Centro de Ciências Exatas e Tecnologias, Universidade Federal do Maranhão-UFMA, São Luís, Maranhão, Brazil., Justino de Araújo AC; Laboratório de Microbiologia e Biologia Molecular-LMBM, Universidade Regional do Cariri-URCA, Crato, Ceará, Brazil., Freitas PR; Laboratório de Microbiologia e Biologia Molecular-LMBM, Universidade Regional do Cariri-URCA, Crato, Ceará, Brazil., Roque Paulo CL; Laboratório de Microbiologia e Biologia Molecular-LMBM, Universidade Regional do Cariri-URCA, Crato, Ceará, Brazil., de Sousa AK; Laboratório de Microbiologia e Biologia Molecular-LMBM, Universidade Regional do Cariri-URCA, Crato, Ceará, Brazil.; Centro Universitário Dr. Leão Sampaio-Unileão Juazeiro do Norte, Juazeiro do Norte, Ceará, Brazil., Rocha JE; Laboratório de Microbiologia e Biologia Molecular-LMBM, Universidade Regional do Cariri-URCA, Crato, Ceará, Brazil., Garcia Leandro LM; Centro Universitário Dr. Leão Sampaio-Unileão Juazeiro do Norte, Juazeiro do Norte, Ceará, Brazil., Macedo da Silva RO; Centro Universitário Dr. Leão Sampaio-Unileão Juazeiro do Norte, Juazeiro do Norte, Ceará, Brazil., Costa Dos Santos C; Departamento de Física, Centro de Ciências Exatas e Tecnologias, Universidade Federal do Maranhão-UFMA, São Luís, Maranhão, Brazil., Ribeiro-Filho J; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, IGM-FIOCRUZ/BA, Salvador, Bahia, Brazil., da Luz Lima C; Departamento de Física, Centro de Ciências da Natureza, Universidade Federal do Piauí-UFPI, Teresina, Piauí, Brazil., Siyadatpanah A; Ferdows School of Paramedical and Health, Birjand University of Medical Sciences, Birjand, Iran., Seifi Z; Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan 49189-36316, Iran., Kim B; Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.; Korean Medicine-Based Drug Repositioning Cancer Research Center, College of Korean Medicine, Kyung Hee University, Seoul 02447, Republic of Korea., Coutinho HDM; Laboratório de Microbiologia e Biologia Molecular-LMBM, Universidade Regional do Cariri-URCA, Crato, Ceará, Brazil.
Jazyk: angličtina
Zdroj: Bioinorganic chemistry and applications [Bioinorg Chem Appl] 2022 Jul 09; Vol. 2022, pp. 2260083. Date of Electronic Publication: 2022 Jul 09 (Print Publication: 2022).
DOI: 10.1155/2022/2260083
Abstrakt: The present study reports the synthesis, characterization, and antibacterial properties of silver trimolybdate (Ag 2 Mo 3 O 10 .2H 2 O) nanorods. The synthesis was performed using a conventional hydrothermal method. The sample was characterised by scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, UV-Vis-NIR diffuse reflectance, thermogravimetric analysis (TGA), and differential scanning calorimeter (DSC). The direct antibacterial activity was evaluated using the microdilution method to determine the minimum inhibitory concentration (MIC). To assess the ability of Ag 2 Mo 3 O 10 .2H 2 O nanorods to modulate antibacterial resistance, the MIC of aminoglycosides was established in the presence of a subinhibitory concentration of this substance alone and associated with LED light exposure. The characterization of the sample indicated that the synthesis of silver trimolybdate generated nanometric crystals with rod-like morphology, without secondary phases. The treatment with Ag 2 Mo 3 O 10 .2H 2 O nanorods alone or combined with visible LED lights exhibited clinically relevant antibacterial activity against both Gram-negative and Gram-positive bacteria. This nanostructure presented a variable antibiotic-modulating action, which was not improved by visible LED light exposure. Nevertheless, LED lights showed promising antibiotic-enhancing activities in the absence of Ag 2 Mo 3 O 10 .2H 2 O nanorods. In conclusion, silver trimolybdate dihydrate nanorods have antibacterial properties that can be photocatalysed by visible-light exposure. While showing the potential use to combat antibacterial resistance, the simultaneous combination of silver trimolybdate, visible LED lights, and antibacterial drugs should be carefully analysed to avoid antagonist effects that could impair the effectiveness of antibiotic therapy.
Competing Interests: The authors declare that there are no conflicts of interest.
(Copyright © 2022 Maria Karollyna do Nascimento Silva Leandro et al.)
Databáze: MEDLINE
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