A simple proteinuria-based risk score predicts contrast-associated acute kidney injury after percutaneous coronary intervention.

Autor: Fujiwara W; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan. wakayafj@fujita-hu.ac.jp., Ishii H; Department of Cardiovascular Medicine, Graduate School of Medicine, Gunma University, Maebashi, Japan., Sobue Y; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Shimizu S; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Ishiguro T; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Yamada R; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Ueda S; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Nishimura H; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Niwa Y; Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan., Miyazaki A; Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan., Miyagi W; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Takahara S; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Naruse H; Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan., Ishii J; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Kiyono K; Division of Bioengineering, Graduate School of Engineering Science, Osaka University, Suita, Japan., Watanabe E; Division of Cardiology, Department of Internal Medicine, Fujita Health University Bantane Hospital, 3-6-10 Otobashi, Nakagawa, Nagoya, 454-8509, Japan., Izawa H; Department of Cardiology, Fujita Health University School of Medicine, Toyoake, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jul 19; Vol. 12 (1), pp. 12331. Date of Electronic Publication: 2022 Jul 19.
DOI: 10.1038/s41598-022-16690-6
Abstrakt: Contrast-associated acute kidney injury (CA-AKI) is a complication of percutaneous coronary intervention (PCI). Because proteinuria is a sentinel marker of renal dysfunction, we assessed its role in predicting CA-AKI in patients undergoing PCI. A total of 1,254 patients undergoing PCI were randomly assigned to a derivation (n = 840) and validation (n = 414) dataset. We identified the independent predictors of CA-AKI where CA-AKI was defined by the new criteria issued in 2020, by a multivariate logistic regression in the derivation dataset. We created a risk score from the remaining predictors. The discrimination and calibration of the risk score in the validation dataset were assessed by the area under the receiver-operating characteristic curves (AUC) and Hosmer-Lemeshow test, respectively. A total of 64 (5.1%) patients developed CA-AKI. The 3 variables of the risk score were emergency procedures, serum creatinine, and proteinuria, which were assigned 1 point each based on the correlation coefficient. The risk score demonstrated a good discriminative power (AUC 0.789, 95% CI 0.766-0.912) and significant calibration. It was strongly associated with the onset of CA-AKI (Cochran-Armitage test, p < 0.0001). Our risk score that included proteinuria was simple to obtain and calculate, and may be useful in assessing the CA-AKI risk before PCI.
(© 2022. The Author(s).)
Databáze: MEDLINE
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