Genomic epidemiology of SARS-CoV-2 in a university outbreak setting and implications for public health planning.

Autor: Nickbakhsh S; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK. Sema.Nickbakhsh@phs.scot.; Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Graham Kerr Building, Glasgow, G12 8QQ, UK. Sema.Nickbakhsh@phs.scot., Hughes J; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK.; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Christofidis N; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK., Griffiths E; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK., Shaaban S; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK., Enright J; School of Computing Science, University of Glasgow, 18 Lilybank Gardens, Glasgow, G12 8RZ, UK., Smollett K; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Nomikou K; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Palmalux N; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Tong L; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Carmichael S; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Sreenu VB; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Orton R; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Goldstein EJ; West of Scotland Specialist Virology Centre, NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, New Lister Building, Glasgow, G31 2ER, UK., Tomb RM; West of Scotland Specialist Virology Centre, NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, New Lister Building, Glasgow, G31 2ER, UK., Templeton K; Royal Infirmary of Edinburgh, NHS Lothian, 51 Little France Crescent, Edinburgh, EH16 4SA, UK., Gunson RN; West of Scotland Specialist Virology Centre, NHS Greater Glasgow and Clyde, Glasgow Royal Infirmary, New Lister Building, Glasgow, G31 2ER, UK., da Silva Filipe A; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Milosevic C; NHS Greater Glasgow and Clyde, Gartnavel General Hospital, 1055 Great Western Road, Glasgow, G12 0XH, UK., Thomson E; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK.; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Robertson DL; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK.; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK., Holden MTG; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK.; School of Medicine, University of St Andrews, North Haugh, St Andrews, KY16 9TF, UK., Illingworth CJR; MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Road, Glasgow, G61 1QH, UK. Christopher.Illingworth@glasgow.ac.uk.; Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Cambridge, UK. Christopher.Illingworth@glasgow.ac.uk.; MRC Biostatistics Unit, University of Cambridge, East Forvie Building, Forvie Site, Robinson Way, Cambridge, CB2 0SR, UK. Christopher.Illingworth@glasgow.ac.uk., Smith-Palmer A; Public Health Scotland, Meridian Court, 5 Cadogan Street, Glasgow, G2 6QE, UK.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2022 Jul 19; Vol. 12 (1), pp. 11735. Date of Electronic Publication: 2022 Jul 19.
DOI: 10.1038/s41598-022-15661-1
Abstrakt: Whole genome sequencing of SARS-CoV-2 has occurred at an unprecedented scale, and can be exploited for characterising outbreak risks at the fine-scale needed to inform control strategies. One setting at continued risk of COVID-19 outbreaks are higher education institutions, associated with student movements at the start of term, close living conditions within residential halls, and high social contact rates. Here we analysed SARS-CoV-2 whole genome sequences in combination with epidemiological data to investigate a large cluster of student cases associated with University of Glasgow accommodation in autumn 2020, Scotland. We identified 519 student cases of SARS-CoV-2 infection associated with this large cluster through contact tracing data, with 30% sequencing coverage for further analysis. We estimated at least 11 independent introductions of SARS-CoV-2 into the student population, with four comprising the majority of detected cases and consistent with separate outbreaks. These four outbreaks were curtailed within a week following implementation of control measures. The impact of student infections on the local community was short-term despite an underlying increase in community infections. Our study highlights the need for context-specific information in the formation of public health policy for higher educational settings.
(© 2022. The Author(s).)
Databáze: MEDLINE
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