Association of Self-reflection With Cognition and Brain Health in Cognitively Unimpaired Older Adults.
| Autor: | Demnitz-King H; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Gonneaud J; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Klimecki OM; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Chocat A; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Collette F; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Dautricourt S; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Jessen F; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Krolak-Salmon P; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Lutz A; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Morse RM; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Molinuevo JL; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Poisnel G; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Touron E; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Wirth M; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Walker Z; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Chételat G; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden., Marchant NL; From the Division of Psychiatry (H.D.-K., R.M.M., Z.W., N.L.M.-A.R.G.), Faculty of Brain Sciences, University College London, United Kingdom; Normandie Univ (J.G., A.C., S.D., G.P., E.T., G.C.), UNICAEN, INSERM, U1237, PhIND 'Physiopathology and Imaging Neurological Disorders,' Institut Blood and Brain at Caen-Normandie, Cyceron, Caen, France; Clinical Psychology and Behavioural Neuroscience (O.M.K.), Technische Universität Dresden, Germany; GIGA-CRC In Vivo Imaging (F.C.), Université de Liège, Belgium; Department of Psychiatry (F.J.), Medical Faculty, University of Cologne, Germany; Hospices Civils de Lyon (P.K.-S.), Institut du Vielllissement, CRC Vielllissement-Cerveau-Fragilité, France; Lyon Neuroscience Research Center Inserm U1028 (A.L.), CNRS UMR5292, Lyon 1 University, France; Alzheimer's Disease and Other Cognitive Disorders Unit (J.L.M.), Hospital Clinic, IDIBAPS, Barcelona, Spain; and German Center for Neurodegenerative Diseases (DZNE) (M.W.), Dresden. n.marchant@ucl.ac.uk. |
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| Jazyk: | angličtina |
| Zdroj: | Neurology [Neurology] 2022 Sep 27; Vol. 99 (13), pp. e1422-e1431. Date of Electronic Publication: 2022 Jul 19. |
| DOI: | 10.1212/WNL.0000000000200951 |
| Abstrakt: | Background and Objectives: Self-reflection (the active evaluation of ones thoughts, feelings, and behaviors) can confer protection against adverse health outcomes. Its effect on markers sensitive to Alzheimer disease (AD), however, is unknown. The primary objective of this cross-sectional study was to examine the association between self-reflection and AD-sensitive markers. Methods: This study used baseline data from cognitively unimpaired older adults enrolled in the Age-Well clinical trial and older adults with subjective cognitive decline from the SCD-Well clinical trial. In both cohorts, self-reflection was measured via the reflective pondering subscale of the Rumination Response Scale, global cognition assessed via the Preclinical Alzheimer's Cognitive Composite 5, and a modified late-life Lifestyle-for-Brain-Health (LIBRA) index computed to assess health and lifestyle factors. In Age-Well, glucose metabolism and amyloid deposition were quantified in AD-sensitive gray matter regions via fluorodeoxyglucose- and AV45-PET scans, respectively. Associations between self-reflection and AD-sensitive markers (global cognition, glucose metabolism, and amyloid deposition) were assessed via unadjusted and adjusted regressions. Furthermore, we explored whether associations were independent of health and lifestyle factors. To control for multiple comparisons in Age-Well, false discovery rate-corrected p values ( p Results: A total of 134 (mean age 69.3 ± 3.8 years, 61.9% women) Age-Well and 125 (mean age 72.6 ± 6.9 years, 65.6% women) SCD-Well participants were included. Across unadjusted and adjusted analyses, self-reflection was associated with better global cognition in both cohorts (Age-Well: adjusted-β = 0.22, 95% CI 0.05-0.40, p Discussion: Self-reflection was associated with better global cognition in 2 independent cohorts and with higher glucose metabolism after adjustment for covariates. There was weak evidence that relationships were independent from health and lifestyle behaviors. Longitudinal and experimental studies are warranted to elucidate whether self-reflection helps preserve cognition and glucose metabolism or whether reduced capacity to self-reflect is a harbinger of cognitive decline and glucose hypometabolism. Trial Registration Information: Age-Well: NCT02977819; SCD-Well: NCT03005652. (© 2022 American Academy of Neurology.) |
| Databáze: | MEDLINE |
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