Brain morphology predictors of alcohol, tobacco, and cannabis use in adolescence: A systematic review.

Autor: Boer OD; Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Science, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry, University Medical Center Rotterdam, Erasmus MC, Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands. Electronic address: o.d.boer@essb.eur.nl., El Marroun H; Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Science, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry, University Medical Center Rotterdam, Erasmus MC, Sophia Children's Hospital, 3000 CB Rotterdam, the Netherlands. Electronic address: h.marrounel@erasmusmc.nl., Franken IHA; Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioral Science, Erasmus University Rotterdam, 3000 DR Rotterdam, the Netherlands. Electronic address: franken@essb.eur.nl.
Jazyk: angličtina
Zdroj: Brain research [Brain Res] 2022 Nov 15; Vol. 1795, pp. 148020. Date of Electronic Publication: 2022 Jul 16.
DOI: 10.1016/j.brainres.2022.148020
Abstrakt: In the last decade, extensive research has emerged on the predictive value of brain morphology for substance use initiation and related problems during adolescence. This systematic review provides an overview of longitudinal studies on pre-existing brain variations and later initiation of alcohol, tobacco, and cannabis use (N = 18). Adolescent structural neuroimaging studies that started before substance use initiation suggest that a smaller anterior cingulate cortex (ACC) volume, thicker or smaller superior frontal gyrus, and larger nucleus accumbens (NAcc) volume are associated with future alcohol use. Also, both smaller and larger orbitofrontal cortex (OFC) volumes were associated with future cannabis and combined alcohol/cannabis use. Smaller amygdala volumes were related to future daily tobacco smoking. These findings could point to specific vulnerabilities for adolescent substance use, as these brain areas are involved in cognitive control (ACC), reward (NAcc), motivation (OFC), and emotional memory (amygdala). However, the reported findings were inconsistent in directionality and laterality, and the largest study on alcohol use predictors reported null findings. Therefore, large population-based longitudinal studies should investigate the robustness and mechanisms of these associations. We suggested future research directions regarding sample selection, timing of baseline and follow-up measurements, and a harmonization approach of study methods.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2022 The Authors. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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