Generation of human induced pluripotent stem cell lines carrying heterozygous PLN mutation from dilated cardiomyopathy patients.

Autor:	Caudal A; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Mondejar-Parreño G; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Vera CD; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Williams DR; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Shenoy SP; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Liang D; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA., Wu JC; Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA; Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Radiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: joewu@stanford.edu.
Jazyk:	angličtina
Zdroj:	Stem cell research [Stem Cell Res] 2022 Aug; Vol. 63, pp. 102855. Date of Electronic Publication: 2022 Jul 11.
DOI:	10.1016/j.scr.2022.102855
Abstrakt:	Familial dilated cardiomyopathy (DCM) is among the most prevalent forms of inherited heart disease. Here, two human-induced pluripotent stem cell (iPSC) lines were generated from peripheral blood mononuclear cells (PBMCs) from DCM patients carrying different mutations in the phospholamban encoding-gene (PLN). Both iPSC lines exhibited normal morphology, karyotype, pluripotency marker expression, and differentiation into the three germ layers. These patient-specific iPSC lines serve as valuable in vitro models for DCM pathology caused by PLN mutations. (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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