Rapidly evolving Creutzfeldt-Jakob disease in COVID-19: from early status epilepticus to fatal outcome.

Autor: Olivo S; Neurology Unit, Department of Medical, Surgical and Health Sciences, Cattinara University Hospital , University of Trieste , Trieste, Italy., Furlanis G; Neurology Unit, Department of Medical, Surgical and Health Sciences, Cattinara University Hospital , University of Trieste , Trieste, Italy. giovanni.furlanis@asugi.sanita.fvg.it., Buoite Stella A; Neurology Unit, Department of Medical, Surgical and Health Sciences, Cattinara University Hospital , University of Trieste , Trieste, Italy., Fabris M; Laboratory of Immunopathology, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy., Milanic R; Laboratory of Immunopathology, Institute of Clinical Pathology, University Hospital of Udine, Udine, Italy., Zanusso G; Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Policlinico G. B. Rossi, Verona, Italy., Manganotti P; Neurology Unit, Department of Medical, Surgical and Health Sciences, Cattinara University Hospital , University of Trieste , Trieste, Italy.
Jazyk: angličtina
Zdroj: Acta neurologica Belgica [Acta Neurol Belg] 2023 Aug; Vol. 123 (4), pp. 1553-1556. Date of Electronic Publication: 2022 Jul 19.
DOI: 10.1007/s13760-022-02023-x
Abstrakt: We report the case of a 70-year-old man coming to our attention for new onset refractory status epilepticus (NORSE) in a rapidly evolving CJD during SARS-CoV-2 co-infection. Our case report describes a fulminant CJD evolution associated with SARS-CoV-2 infection, which led to patient death after 15 days from admission. First EEG presented continuous diffuse spikes, sharp waves and sharp-and-slow wave complexes, pattern consistent with a non-convulsive status epilepticus (NORSE). Our case supports how CJD with SARS-CoV-2 co-infection could be characterized by an accelerated evolution, as already hypothesize for others microorganism infections, and how the diagnosis might be more challenging due to its uncommon presentations, such as NORSE.
(© 2022. The Author(s) under exclusive licence to Belgian Neurological Society.)
Databáze: MEDLINE