| Autor: |
Wang LY; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Xia GY; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Wang M; Key Laboratory for Qinghai-Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmaceutical, Qinghai Nationalities University, Xining 810007, China., Wu YZ; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Wang YN; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China., Chai LM; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China., Lin S; Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China.; Key Laboratory for Qinghai-Tibet Plateau Phytochemistry of Qinghai Province, College of Pharmaceutical, Qinghai Nationalities University, Xining 810007, China. |
| Abstrakt: |
A new polyketide derivative containing a 3-hydroxydecanoic acid ester moiety, penicipurate A ( 1 ), was purified from the solid cultures of the fungus Penicillium purpurogenum , a fungal strain endophytic in the leaves of Edgeworthia chrysantha . The structure of 1 was established by spectroscopic methods, including UV, IR, HRESIMS, 1D, and 2D NMR and 13 C NMR chemical shifts calculations coupled with DP4+ analysis, as well as the chemical degradation method. Compound 1 showed moderate inhibitory activity against pancreatic lipase (PL) with an IC 50 value of 9.61 ± 1.42 µM. |
