Polycaprolactone/chlorinated bioglass scaffolds doped with Mg and Li ions: Morphological, physicochemical, and biological analysis.

Autor: Kukulka EC; Department of Dental Materials and Prosthesis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil., de Souza JR; Department of Dental Materials and Prosthesis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil., de Araújo JCR; Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil., de Vasconcellos LMR; Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil., Campos TMB; Department of Physics, Technological Institute of Aeronautics (ITA), São José dos Campos, Brazil., Thim GP; Department of Physics, Technological Institute of Aeronautics (ITA), São José dos Campos, Brazil., Borges ALS; Department of Dental Materials and Prosthesis, Institute of Science and Technology, São Paulo State University (UNESP), São José dos Campos, Brazil.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2023 Jan; Vol. 111 (1), pp. 140-150. Date of Electronic Publication: 2022 Jul 19.
DOI: 10.1002/jbm.b.35140
Abstrakt: The objective was to synthesize and characterize fine polycaprolactone (PCL) fibers associated with a new 58S bioglass obtained by the precipitated sol-gel route, produced by the electrospinning process in order to incorporate therapeutic ions (Mg and Li). In PCL/acetone solutions were added 7% pure bioglass, bioglass doped with Mg(NO 3 ) 2 and Li 2 CO 3 and were subjected to electrospinning process. The fibers obtained were characterized morphologically, chemically and biologically. The results showed the presence of fine fibers at the nanometric scale and with diameters ranging from 0.67 to 1.92 μm among groups. Groups containing bioglass showed particles both inside and on the surface of the fibers. The components of the polymer, bioglass and therapeutic ions were present in the fibers produced. The produced fibers showed cell viability and induced the formation of mineralization nodules. It was observed the applicability of that methodology in making an improved biomaterial, which adds the osteoinductive properties of the bioglass to PCL and to those of therapeutic ions, applicable to guided bone regeneration.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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