Optimal theranostic SPECT imaging protocol for 223radium dichloride therapy.
| Autor: | Lima LFC; Nuclear Instrumentation Laboratory (COPPE/UFRJ), Brazil. Electronic address: felipelima2005@yahoo.com.br., Pinto GM; Sao Carlos Oncological Health, Brazil., da Silva CCO; Nuclear Engineering Program (COPPE/UFRJ), Brazil., Fuser DC; Sao Carlos Oncological Health, Brazil., Gama MP; Statistics Federal Council, Brazil., Griebler CF; Radioprotection Dosimetry Institute (IRD), Brazil., Bonifacio DAB; Radioprotection Dosimetry Institute (IRD), Brazil., de Sá LV; Radioprotection Dosimetry Institute (IRD), Brazil., Lopes RT; Nuclear Instrumentation Laboratory (COPPE/UFRJ), Brazil. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of medical imaging and radiation sciences [J Med Imaging Radiat Sci] 2022 Sep; Vol. 53 (3), pp. 374-383. Date of Electronic Publication: 2022 Jul 16. |
| DOI: | 10.1016/j.jmir.2022.06.009 |
| Abstrakt: | 223 Radium dichloride image-based individual dosimetry requires an optimal acquisition and reconstruction protocol and proper image correction methods for theranostic applications. To assess this problem, radium-223 dichloride SPECT images were acquired from a Jaszczak simulator with a dual-headed gamma camera, LEHR collimator, 128 × 128 matrix, and total time of 32 minutes. A cylindrical PMMA phantom was used to calibrate the measurements performed with Jaszczak. The image quality parameters (noise coefficient, contrast, contrast-to-noise ratio and recovery coefficient) and septal penetration correction were calculated by MATLAB®. The best results for the investigated image quality parameters were obtained with an 89 keV energy window (24% wide) produced together with OSEM/MLEM reconstruction (8 subsets and 4 iterations) applying a Butterworth filter (order 10 and cutoff frequency of 0.48 cycles·cm -1 ). The successfully performed recovery coefficient parameter evaluation allows uptake correction for future patient dosimetry applications. (Copyright © 2022. Published by Elsevier Inc.) |
| Databáze: | MEDLINE |
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