High prevalence of sexual infection by human papillomavirus and Chlamydia trachomatis in sexually-active women from a large city in the Amazon region of Brazil.

Autor: Dos Santos LM; Laboratory of Molecular and Cellular Biology, Tropical Medicine Center, Universidade Federal do Pará, Belém, Pará, Brazil.; Tropical Medicine Center, Universidade Federal do Pará, Belém, Pará, Brazil., de Souza JD; Institute of Biological Sciences, Universidade Federal do Pará, Belém, Pará, Brazil., Mbakwa HA; Graduation in Medicine, Universidade Federal do Pará, Belém, Pará, Brazil., Nobre AFS; Laboratory of Molecular and Cellular Biology, Tropical Medicine Center, Universidade Federal do Pará, Belém, Pará, Brazil., Vieira RC; Laboratory of Molecular and Cellular Biology, Tropical Medicine Center, Universidade Federal do Pará, Belém, Pará, Brazil., Ferrari SF; Department of Ecology, Universidade Federal de Sergipe, São Cristóvão, Brazil., Rodrigues AR; Tropical Medicine Center, Universidade Federal do Pará, Belém, Pará, Brazil., Ishikawa EAY; Laboratory of Molecular and Cellular Biology, Tropical Medicine Center, Universidade Federal do Pará, Belém, Pará, Brazil., Guerreiro JF; Institute of Biological Sciences, Universidade Federal do Pará, Belém, Pará, Brazil., de Sousa MS; Laboratory of Molecular and Cellular Biology, Tropical Medicine Center, Universidade Federal do Pará, Belém, Pará, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Jul 18; Vol. 17 (7), pp. e0270874. Date of Electronic Publication: 2022 Jul 18 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0270874
Abstrakt: Background: The Human Papillomavirus (HPV) and Chlamydia trachomatis are the most prevalent Sexually Transmitted Infections (STIs) worldwide, and are associated cervical cancer and pelvic inflammatory disease, respectively. However, 80% of women testing positive are asymptomatic. In the Amazon region, young women, in particular, are widely exposed to the infections and their consequences.
Objectives: Determine the prevalence of sexual infection by HPV and C. trachomatis in young, sexually-active women treated at a university health program in a large city of the Brazilian Amazon region.
Methods: We amplified the L1 gene of HPV. We amplified ompA gene of C. trachomatis by nested PCR, and the study participants filled in a questionnaire on their social, epidemiological, and reproductive health characteristics. The data were analyzed using the Odds Ratio, to evaluate the degree of association of these variables with the observed infections.
Results: The prevalence of infection by HPV was 15.5% (47/303). This infection was recorded in 32.2% of the women of less than 25 years of age (OR:3.02 [CI95%] = 1.32-6.92; p = 0.014), 17.9% of the single women (OR: 2.41 [CI95%] = 1.22-4.75; p = 0.014), 23.8% of the women that reported having first sexual intercourse at less than 15 years of age (OR: 2.22 [CI95%] = 1.16-4.23; p = 0.021), 20% of those that reported having had more than one sexual partner during their lifetime (OR: 3.83 [CI95%] = 1.56-9.37; p = 0.003), and in 28.3% that use oral contraceptives (CI95% = 1.33-5.43; p = 0.008). The prevalence of sexual infection by C. trachomatis was 4.6% (14/303), and this bacterium was present in 16.1% of the young women of less than 25 years of age (OR: 2.86 [CI95%] = 1.33-5.43; p = 0.008).
Conclusions: We found a high prevalence of HPV in young, unmarried women who started their sex lives early, who had several sexual partners in their lives and who used oral contraceptives. The prevalence of C. trachomatis was high only in young women. Our data are in accordance with other studies in Brazil and in the world and may serve to base the formulation of diagnostic and screening measures for these infections in women in the Amazon.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje