Relationship Between Preoperative NT-proBNP and Postoperative Adverse Events in Patients with Left Ventricular Assist Device.

Autor: Beyazal OF; University of Health Sciences, Ankara City Hospital, Cardiovascular Surgery, Cankaya, Ankara, Turkey., Kervan Ü; University of Health Sciences, Ankara City Hospital, Cardiovascular Surgery, Cankaya, Ankara, Turkey., Karahan M; University of Health Sciences, Ankara City Hospital, Cardiovascular Surgery, Cankaya, Ankara, Turkey., Kocabeyoğlu SS; University of Health Sciences, Ankara City Hospital, Cardiovascular Surgery, Cankaya, Ankara, Turkey., Sert DE; University of Health Sciences, Ankara City Hospital, Cardiovascular Surgery, Cankaya, Ankara, Turkey., Temizhan A; University of Health Sciences, Ankara City Hospital, Cardiology, Cankaya, Ankara, Turkey., Demirkan B; University of Health Sciences, Ankara City Hospital, Cardiology, Cankaya, Ankara, Turkey., Akdi M; University of Health Sciences, Ankara City Hospital, Cardiovascular Surgery, Cankaya, Ankara, Turkey., Konşuk Ünlü H; Institute of Public Health, Hacettepe University, Ankara, Turkey., Çatav Z; University of Health Sciences, Ankara City Hospital, Cardiovascular Surgery, Cankaya, Ankara, Turkey.
Jazyk: angličtina
Zdroj: The International journal of artificial organs [Int J Artif Organs] 2022 Oct; Vol. 45 (10), pp. 817-825. Date of Electronic Publication: 2022 Jul 16.
DOI: 10.1177/03913988221111406
Abstrakt: Background: The aim of this study is to investigate the relationship of preoperative NT-proBNP values with postoperative adverse events in patient left ventricular assist device (LVAD) implantation.
Method: Forty-six patients (35 males; mean age 49.4 ± 12.9 years) who underwent LVAD implantation between 2016 and 2018 were evaluated in this study. The analysis was made on the relationship between preoperative NT-proBNP and mortality, postoperative right ventricular failure (RVF), postoperative drainage, duration of intubation, and intensive care unit stay, was examined. The optimal NT-proBNP cut-off values for predicting mortality were determined using Receiver Operator Characteristic (ROC) curve analysis and the patients were divided into two groups according to the specified cut-off point.
Result: Median NT-proBNP was higher in patients who died, had postoperative extracorporeal membrane oxygenation, and early RVF. The median NT-proBNP was 11,103 pg/ml in patients with IABP, and 2943 pg/ml in patients without IABP, and the difference was statistically significant ( p  = 0.002). The cut-off point for NT-proBNP was found to be 1725.5 pg/ml (Sensitivity:0.929, Specificity:0.688). Accordingly, when the patients were divided into two groups and analyzed, no statistically significant difference was found between preoperative NT-proBNP below or above 1725.5 and postoperative adverse events. There was no statistically significant correlation between preoperative NT-proBNP and postoperative drainage, duration of intubation time, and duration of ICU stay ( p  > 0.05).
Conclusion: Routine monitoring of preoperative NT-proBNP and comparison with postoperative values are important in terms of patient selection, the timing of surgery, follow-up of postoperative adverse events, and improving outcomes in VAD patients.
Databáze: MEDLINE
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