Declining trends of prevalence of Helicobacter pylori infection and incidence of gastric cancer in Taiwan: An updated cross-sectional survey and meta-analysis.

Autor: Chen MJ; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Integrated Diagnostics and Therapeutics, National Taiwan University Hospital, National Taiwan University College of Medicine, Taipei, Taiwan., Bair MJ; Division of Gastroenterology, Department of Internal Medicine, Taitung Mackay Memorial Hospital, Taitung, Taiwan.; Mackay Medical College, New Taipei City, Taiwan., Chen PY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chia-Yi Christian Hospital, Chia-Yi, Taiwan., Lee JY; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin, Taiwan., Yang TH; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin, Taiwan., Fang YJ; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin, Taiwan., Chen CC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Chang AT; Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan., Hsiao WD; Division of Hepatogastroenterology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan., Yu JJ; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin, Taiwan., Kuo CC; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin, Taiwan., Chiu MC; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Yun-Lin, Taiwan., Lin KP; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Geriatrics and Gerontology, National Taiwan University Hospital, Taipei, Taiwan., Tsai MH; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Hsin-Chu, Taiwan., Hsu YC; Department of Internal Medicine, E-DA Hospital and I-Shou University, Kaohsiung, Taiwan., Chou CK; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chia-Yi Christian Hospital, Chia-Yi, Taiwan., Chen CY; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Chia-Yi Christian Hospital, Chia-Yi, Taiwan., Lin JT; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Digestive Medicine Center, China Medical University Hospital, Taichung, Taiwan., Lee YC; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Wu MS; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan., Liou JM; Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan.; Department of Internal Medicine, National Taiwan University Cancer Center, Taipei, Taiwan.
Jazyk: angličtina
Zdroj: Helicobacter [Helicobacter] 2022 Oct; Vol. 27 (5), pp. e12914. Date of Electronic Publication: 2022 Jul 18.
DOI: 10.1111/hel.12914
Abstrakt: Background: We aimed to assess the latest prevalence and secular trend of Helicobacter pylori infection and its association with the incidence and mortality of gastric cancer in Taiwan.
Materials and Methods: Adults naive to H. pylori eradication received 13 C-urea breath test ( 13 C-UBT), H. pylori stool antigen test, and serology test during 2019-2020 in this prospective screening program. Children and adolescent aged between 7 and 19 years received 13 C-UBT for H. pylori screening. We also conducted a systematic review and meta-analysis to assess the secular trend of prevalence of H. pylori from 1990 to 2020 in Taiwan. The secular trends of age-standardized incidence and mortality of gastric cancer were obtained from the Taiwan Cancer Registry.
Results: A total of 1494 participants were enrolled, including 294 children or adolescents and 1200 adults. The overall prevalence of active H. pylori infection by 13 C-UBT was 26.6% (397/1494), which was 30.8% in adults and 9.5% in adolescents/children. The age-standardized prevalence of active H. pylori infection was 32.3% in adults after adjustment of the population structure in Taiwan. Of the 29 studies including 38,597 subjects eligible for the meta-analysis, the pooled prevalence of H. pylori infection decreased from 63.8% (95% CI: 55.9%-71%) in 1990-2000 to 28.2% (95% CI:21.8%-35.6%) in 2016-2020. The age-standardized incidence and mortality of gastric cancer have also declined from 15.2 to 10.75 per 100,000, respectively, in 1999 to 9.29 and 5.4 per 100,000, respectively, in 2019.
Conclusions: The prevalence of H. pylori infection has declined in Taiwan, which correlates with the declining trends of age-standardized incidence and mortality of gastric cancer in Taiwan.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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