COVID-19 Associated Mucormycosis with Newly Diagnosed Diabetes Mellitus in Young Males - A Tertiary Care Experience.

Autor: Kapoor S; Department of Otorhinolaryngology, Faculty of Medicine and Health Sciences, Shree Guru Gobind Singh Tricentenary University, Haryana, India., Saidha PK; Department of Otorhinolaryngology, Faculty of Medicine and Health Sciences, Shree Guru Gobind Singh Tricentenary University, Haryana, India., Gupta A; Department of Otorhinolaryngology, Faculty of Medicine and Health Sciences, Shree Guru Gobind Singh Tricentenary University, Haryana, India., Saini U; Department of Otorhinolaryngology, Faculty of Medicine and Health Sciences, Shree Guru Gobind Singh Tricentenary University, Haryana, India., Satya S; Department of Anesthesia, Faculty of Medicine and Health Sciences, Shree Guru Gobind Singh Tricentenary University, Gurugram, Haryana, India.
Jazyk: angličtina
Zdroj: International archives of otorhinolaryngology [Int Arch Otorhinolaryngol] 2022 Jul 14; Vol. 26 (3), pp. e470-e477. Date of Electronic Publication: 2022 Jul 14 (Print Publication: 2022).
DOI: 10.1055/s-0042-1748927
Abstrakt: Introduction  Patients with a history of or active COVID-19 infection are predisposed to the development of opportunist bacterial and fungal infections. A rising incidence of a rare occurring fungal infection earlier, called mucormycosis, has been reported in abundance across the globe since March 2021, especially in India just as the second wave of COVID-19 began, caused by the trifecta of hyperglycemia (new-onset or exacerbation of pre-existing diabetes), oxygen therapy (invasive or noninvasive ventilation), and prolonged intake of steroids. Objective  The present study aimed at assessing the prevalence of post-COVID mucormycosis in males of younger age group and spread of rhino-orbital-cerebral mucormycosis (ROCM). Methods  A case-control study was performed over a period of 3 months among 60 male patients with confirmed diagnosis of mucormycosis. Individuals < 40 years old were included in the case group ( n  = 30), while those > 40 years old were included as controls ( n  = 30). Disease spread was assessed in three types of ROCM, that is, rhinomaxillary, rhino-orbital, and rhino-orbito-cerebral mucormycosis. Results  In the control group, the mean age was 48.47 years old, the mean HbA1c was 10.62 ± 1.88%, with most of them suffering from rhino-orbital mucormycosis. In the case group, the mean age was 31.57 years old, with a mean HbA1c of 10.11 ± 2.46%, and most patients had rhinomaxillary mucormycosis. The duration of steroid intake and mode of oxygen therapy were found to be significant in the severity of ROCM. Conclusion  Rising cases of post-COVID mucormycosis have brought to light the fatal consequences of prolonged use of steroids and oxygen therapy towards the development and spread of ROCM among young and middle-aged males.
Competing Interests: Conflict of Interests The authors have no conflict of interests to declare.
(Fundação Otorrinolaringologia. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commecial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
Databáze: MEDLINE
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