Streamlined and Robust Stage-Specific Profiling of Gametocytocidal Compounds Against Plasmodium falciparum .
| Autor: | Reader J; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa., van der Watt ME; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa.; Institute for Sustainable Malaria Control, School of Health Systems and Public Health, University of Pretoria, Pretoria, South Africa., Birkholtz LM; Department of Biochemistry, Genetics and Microbiology, University of Pretoria, Pretoria, South Africa. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Jun 30; Vol. 12, pp. 926460. Date of Electronic Publication: 2022 Jun 30 (Print Publication: 2022). |
| DOI: | 10.3389/fcimb.2022.926460 |
| Abstrakt: | Malaria elimination is dependent on the ability to target both the pathogenic and transmissible stages of the human malaria parasite, Plasmodium falciparum . These forms of the parasite are differentiated by unique developmental stages, each with their own biological mechanisms and processes. These individual stages therefore also respond differently to inhibitory compounds, and this complicates the discovery of multistage active antimalarial agents. The search for compounds with transmission-blocking activity has focused on screening for activity on mature gametocytes, with only limited descriptions available for the activity of such compounds on immature stage gametocytes. This therefore poses a gap in the profiling of antimalarial agents for pan-reactive, multistage activity to antimalarial leads. Here, we optimized an effective and robust strategy for the simple and cost-effective description of the stage-specific action of gametocytocidal antimalarial compounds. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Reader, van der Watt and Birkholtz.) |
| Databáze: | MEDLINE |
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