Entourage effect for phenolic compounds on production and metabolism of mammary epithelial cells.

Autor:	Shalev Y; Department of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel., Hadaya O; Department of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.; Department of Natural Resources, Institute of Plant Sciences, Agricultural Research Organization - the Volcani Center, Rishon LeZion, 7505101, Israel., Bransi-Nicola R; Institute of Applied Research, The Galilee Society, P.O. Box 437, Shefa-Amr, 20200, Israel., Landau SY; Department of Natural Resources, Institute of Plant Sciences, Agricultural Research Organization - the Volcani Center, Rishon LeZion, 7505101, Israel., Azaizeh H; Institute of Applied Research, The Galilee Society, P.O. Box 437, Shefa-Amr, 20200, Israel.; Department of Natural Resources & Environmental Management, University of Haifa, Haifa, 3498838, Israel.; Tel Hai College, Department of Environmental Science, Upper Galilee, 12208, Israel., Muklada H; Department of Natural Resources, Institute of Plant Sciences, Agricultural Research Organization - the Volcani Center, Rishon LeZion, 7505101, Israel., Glasser T; Ramat HaNadiv Nature Park, Zikhron Yaakov, Israel., Roth Z; Department of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel., Deutch-Traubman T; Department of Natural Resources, Institute of Plant Sciences, Agricultural Research Organization - the Volcani Center, Rishon LeZion, 7505101, Israel., Haj-Zaroubi M; Institute of Applied Research, The Galilee Society, P.O. Box 437, Shefa-Amr, 20200, Israel.; Department of Natural Resources & Environmental Management, University of Haifa, Haifa, 3498838, Israel., Argov-Argaman N; Department of Animal Sciences, Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, 7610001, Israel.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2022 Mar 15; Vol. 8 (3), pp. e09025. Date of Electronic Publication: 2022 Mar 15 (Print Publication: 2022).
DOI:	10.1016/j.heliyon.2022.e09025
Abstrakt:	Primary culture of mammary epithelial cells (MEC) was exposed to ethyl-acetate, chloroform and hexane extracts of Pistacia lentiscus (lentisk). The hexane extract contained mainly ethyl gallate whereas the chloroform extract contained mainly ethyl-gallate with smaller amount of gallic acid, and the ethyl-acetate extract contained mainly rutin, gallic acid and myricetin. Ethyl acetate extract increased secretion of protein and fat and improved mitochondrial activity. The enhancing effect on protein production was attributed to myricetin, one of the polyphenols in the ethyl-acetate extract whereas gallic acid did not affect protein production or secretion. Interestingly, exposure to the isolated polyphenols did not improve mitochondrial productivity and activity as effectively as exposure to the complete plant extract. The results indicated that polyphenols improve production of milk constituents by MEC, through different modes of action for different polyphenols suggesting an additive or even synergistic effect on production traits of mammary cells. Competing Interests: The authors declare no conflict of interest. (© 2022 Published by Elsevier Ltd.)
Databáze:	MEDLINE
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