Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats.

Autor:	Agu PC; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Aja PM; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Ekpono Ugbala E; Department of Science Laboratory Technology, Biochemistry Option, Federal Polytechnic Oko, Anambra State, Nigeria., Ogwoni HA; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Ezeh EM; Department of Chemical Engineering, Caritas University, Amorji-Nike, Enugu State, Nigeria., Oscar-Amobi PC; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Asuk Atamgba A; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Cross River University of Technology (CRUTECH), Nigeria., Ani OG; Department of Clinical Sciences and Nutrition, University of Chester, Parkgate Road Tower Building United Kingdom.; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Awoke JN; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Nwite FE; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Ukachi OU; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Orji OU; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Nweke PC; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Ekpono Ugbala E; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Ewa GO; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Igwenyi IO; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Egwu CO; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria., Alum EU; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Chukwu DC; Department of Biochemistry, Faculty of Science, Ebonyi State University, Abakaliki, Nigeria., Famurewa AC; Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria.
Jazyk:	angličtina
Zdroj:	Heliyon [Heliyon] 2022 Mar 24; Vol. 8 (3), pp. e09162. Date of Electronic Publication: 2022 Mar 24 (Print Publication: 2022).
DOI:	10.1016/j.heliyon.2022.e09162
Abstrakt:	Background: Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. Cucumeropsis mannii seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. Methods: A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. Results: BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. Conclusions: CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity. Competing Interests: The authors declare no competing interests. (© 2022 The Authors. Published by Elsevier Ltd.)
Databáze:	MEDLINE
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