Pretreatment 18 F-FDG PET/CT-Derived Parameters in Predicting Clinical Outcomes of Locally Advanced Upper Third Esophageal Squamous Cell Carcinoma After Definitive Chemoradiation Therapy.

Autor: Ha LN; Department of Nuclear Medicine, 108 Military Central Hospital, Hanoi, Vietnam., Chau ND; Department of Radiation Oncology and Radiosurgery, 108 Military Central Hospital, Hanoi, Vietnam., Bieu BQ; Department of Radiation Oncology and Radiosurgery, 108 Military Central Hospital, Hanoi, Vietnam., Son MH; Department of Nuclear Medicine, 108 Military Central Hospital, Hanoi, Vietnam.
Jazyk: angličtina
Zdroj: Nuclear medicine and molecular imaging [Nucl Med Mol Imaging] 2022 Aug; Vol. 56 (4), pp. 181-187. Date of Electronic Publication: 2022 May 10.
DOI: 10.1007/s13139-022-00751-9
Abstrakt: Purpose: The aim of this study was to investigate whether standard uptake values (SUVs) of pretreatment 18 F-FDG PET/CT were the surrogate parameters for predicting the outcomes in locally advanced esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.
Materials and Methods: Sixty patients with esophageal squamous cell carcinoma underwent pretreatment 18 F-FDG PET/CT and received definitive chemoradiotherapy. 18 F-FDG metabolic parameters including SUVmax, SUVmean, SULpeak, total lesion glycolysis (TLG), and metabolic tumor volume (MTV) of primary tumor were calculated. The receiver-operating characteristic (ROC) curve was used to determine the optimal cutoff value of FDG PET/CT-derived parameters that associated with treatment response. Estimating progression-free survival (PFS) and overall survival (OS) was analyzed by using Kaplan-Meier methods. Univariate and multivariate analysis for PFS and OS was performed using Cox regression.
Results: Complete response was achieved in 38.3%. The 4-year OS and PFS rates were 48.6% and 44.4%, respectively. SUVmean with a cutoff value of 6.1 could predict complete response with sensitivity of 69.6%, specificity of 78.4%, and accuracy of 75%. Cox multi-factor regression analyses revealed SUVmean > 6.1 as an independent prognostic factor for OS (HR = 6.74, p = 0.02) and PFS (HR = 6.53, p < 0.001).
Conclusions: Our study suggests that SUVmean of the primary tumor in pretreatment 18 F-FDG PET/CT may be used as an independent predictor in esophageal squamous cell carcinoma patients treated with definitive chemoradiotherapy.
Competing Interests: Competing InterestsLe Ngoc Ha, Nguyen Dinh Chau, Bui Quang Bieu, and Mai Hong Son declare that they have no conflict of interest.
(© The Author(s), under exclusive licence to Korean Society of Nuclear Medicine 2022.)
Databáze: MEDLINE
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