Phytochemical Analysis and Antioxidant and Antidiabetic Activities of Extracts from Bergenia ciliata , Mimosa pudica , and Phyllanthus emblica .

Autor: Sapkota BK; Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal., Khadayat K; Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal., Sharma K; Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal., Raut BK; Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal., Aryal D; Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal., Thapa BB; Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal., Parajuli N; Biological Chemistry Lab, Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu 44618, Nepal.
Jazyk: angličtina
Zdroj: Advances in pharmacological and pharmaceutical sciences [Adv Pharmacol Pharm Sci] 2022 Jul 07; Vol. 2022, pp. 4929824. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022).
DOI: 10.1155/2022/4929824
Abstrakt: Diabetes is a metabolic disorder of high blood sugar levels which leads to various chronic health-related complications. The digestive enzymes α -amylase and α -glucosidase play a major role in the hydrolysis of starch to glucose; hence, inhibiting these enzymes is considered an important strategy for the treatment of diabetes. Medicinal plants such as Bergenia ciliata , Mimosa pudica , and Phyllanthus emblica are commonly used in traditional remedies due to their numerous health benefits. This study aimed to determine the phytochemicals as well as TPC and TFC contents in these plant extracts along with their antioxidant and enzyme inhibitory activity against α -glucosidase and α -amylase. The ethyl acetate extracts of selected plants have shown higher TPC and TFC contents. The aqueous extract of B. ciliata (IC 50 : 16.99 ± 2.56  μ g/mL) and ethyl acetate extract of P. emblica (IC 50 : 11.98 ± 0.36  μ g/mL) and M. pudica (IC 50 : 21.39 ± 3.76  μ g/mL) showed effective antioxidant activities. Furthermore, ethyl acetate extract of B. ciliata showed significant inhibitory activity against α -amylase and α -glucosidase with IC 50 values of 38.50 ± 1.32  μ g/mL and 3.41 ± 0.04  μ g/mL, respectively. Thus, secondary metabolites of these medicinal plants can be repurposed as effective inhibitors of digestive enzymes.
Competing Interests: There are no conflicts of interest among authors.
(Copyright © 2022 Basanta Kumar Sapkota et al.)
Databáze: MEDLINE
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