Simulation of Mechanical and Thermal Wounds of Soft Tissues.

Autor: Andreev AA; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia., Glukhov AA; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia., Ostroushko AP; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia., Boev SN; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia., Laptieva AY; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia. laptievaa@mail.ru., Grigor'eva EV; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia., Konovalov PA; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia., Arkhipov DV; N. N. Burdenko Voronezh State Medical University, Ministry of Health of the Russian Federation, Voronezh, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2022 Jul; Vol. 173 (3), pp. 287-292. Date of Electronic Publication: 2022 Jul 18.
DOI: 10.1007/s10517-022-05535-x
Abstrakt: Millions of accidental and surgical injuries of soft tissues are registered annually around the world [5]. Untimely and insufficiently effective treatment of wounds in 50-70% leads to the development of purulent-septic infection and the development of septic conditions and fatal outcomes [1-4], which necessitates thorough study of inflammatory and regenerative processes occurring in the injured soft tissues. Various models of mechanical and thermal damage to soft tissues are proposed for studying the inflammatory and reparative processes, for assessing the therapeutic effects and developing new approaches to wound treatment. However, the developed models do not fully meet the requirements of researchers and are not always simple and uniformly reproducible, close to the course of the pathology in humans, and highly reliable. When choosing the model of mechanical and thermal wounds, the experience of other researchers should be taken into consideration due to the need of actualization and improvement of existing models.
(© 2022. Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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