Melatonin regulates antioxidant defense and inflammatory response by activating Nrf2-dependent mechanisms and inhibiting NFkappaB expression in middle-aged T. cruzi infected rats.
Autor: | Brazão V; College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP, Brazil. Electronic address: vbrazao@eerp.usp.br., Colato RP; College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP, Brazil., Santello FH; College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP, Brazil., Duarte A; College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP, Brazil., Goulart A; College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP, Brazil., Sampaio PA; College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP, Brazil., Pacheco Silva CB; Department of Psychiatric Nursing and Human Sciences, Laboratory of Pharmacology, College of Nursing of Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil., Tirapelli CR; Department of Psychiatric Nursing and Human Sciences, Laboratory of Pharmacology, College of Nursing of Ribeirão Preto, USP, Ribeirão Preto, SP, Brazil., Costa RM; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, SP, Brazil; Special Academic Unit of Health Sciences, Federal University of Jatai, Jatai, GO, Brazil., Tostes RC; Department of Pharmacology, Ribeirão Preto Medical School, University of São Paulo, Ribeirao Preto, SP, Brazil., do Prado JC Jr; College of Pharmaceutical Sciences of Ribeirão Preto (FCFRP), University of São Paulo, Ribeirão Preto, SP, Brazil. |
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Jazyk: | angličtina |
Zdroj: | Experimental gerontology [Exp Gerontol] 2022 Oct 01; Vol. 167, pp. 111895. Date of Electronic Publication: 2022 Jul 14. |
DOI: | 10.1016/j.exger.2022.111895 |
Abstrakt: | Oxidative stress with higher levels of leptin and inflammatory response are key processes related to pathogenesis of both T. cruzi infection and aging. Nuclear factor erythroid 2-related factor 2 (Nrf2) controls the expression of several genes implicated in the oxidative stress response in many pathological conditions. Melatonin is a pleiotropic hormone with Competing Interests: Declaration of competing interest None of the authors has any potential financial conflict of interest related to this manuscript. (Copyright © 2022 Elsevier Inc. All rights reserved.) |
Databáze: | MEDLINE |
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