A synthesis of functionalized 3-amino-1,2,4-triazoles from nitrile imines and guanidine derivatives.

Autor: Yavari I; Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran. yavarisa@modares.ac.ir., Taheri Z; Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran., Sheikhi S; Department of Chemistry, Tarbiat Modares University, PO Box 14115-175, Tehran, Iran.
Jazyk: angličtina
Zdroj: Molecular diversity [Mol Divers] 2024 Feb; Vol. 28 (1), pp. 11-18. Date of Electronic Publication: 2022 Jul 17.
DOI: 10.1007/s11030-022-10471-z
Abstrakt: A regioselective synthesis of trisubstituted 1,2,4-triazoles through reaction of nitrile imines with guanidine derivatives is described. These 1,3-dipolar cycloaddition reactions proceeded smoothly in moderate to good yields and excellent regioselectivity under ambient conditions. This method provides fast access to a range of functionalized 3-amino-1,2,4-triazoles.
(© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.)
Databáze: MEDLINE
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