Lymphocyte subsets and Langerhans cells in the skin of kidney transplant recipients under three different immunosuppressive regimens.

Autor: Quaresma MV; Department of Dermatology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil., Azevedo LS; Renal Transplantation Service, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil., Pereira NV; Department of Dermatology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil., Saldanha MG; Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil., David-Neto E; Renal Transplantation Service, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil., Sotto MN; Department of Dermatology, Hospital das Clínicas, University of São Paulo Medical School, São Paulo, Brazil.; Department of Pathology, University of São Paulo Medical School, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: Journal of the European Academy of Dermatology and Venereology : JEADV [J Eur Acad Dermatol Venereol] 2022 Dec; Vol. 36 (12), pp. 2466-2472. Date of Electronic Publication: 2022 Jul 23.
DOI: 10.1111/jdv.18430
Abstrakt: Background: Renal transplant recipients (RTRs) are at increased risk of developing skin cancer; however, the role of immunosuppression is not yet fully understood. In this study, we evaluated the immunohistochemical changes in the skin of RTRs under three different immunosuppression regimens: mTOR inhibitors (mTORi), sirolimus or everolimus, mycophenolic acid (MPA) precursors such as mycophenolate sodium or mofetil, or azathioprine (AZA).
Methods: We evaluated biopsies of sun-exposed and sun-protected skin for immunohistochemical quantification of B lymphocytes (CD20 + ), T lymphocytes (CD3 + , CD4 + , and CD8 + ), and Langerhans cells (LCs) (CD1a + ) in 30 RTRs and 10 healthy controls. The RTRs were divided into three groups: mTORi (n = 10), MPA (n = 10), and AZA (n = 10).
Results: No differences were observed in the number of B lymphocytes. However, a significant decrease in the number of T lymphocytes and LCs was observed in both sun-protected and sun-exposed skin in the AZA and MPA groups, although to a lesser degree in the latter group. The skin of the mTORi group did not differ from that of the control group in terms of the number of B and T lymphocytes and LCs.
Conclusions: Patients treated with mTORi exhibit preserved cellular elements related to cutaneous immune surveillance. The use of AZA induced a greater degree of skin immunosuppression than in the control group, as demonstrated by the decrease in T lymphocytes and LCs.
(© 2022 European Academy of Dermatology and Venereology.)
Databáze: MEDLINE
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