Childhood body mass index and associations with infant gut metabolites and secretory IgA: findings from a prospective cohort study.

Autor: Bridgman SL; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Malmuthuge N; Agriculture Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB, Canada., Mandal R; Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada., Field CJ; Department of Agriculture, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada., Haqq AM; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.; Department of Agriculture, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada., Mandhane PJ; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada., Moraes TJ; Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Turvey SE; Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.; BC Children's Hospital, Vancouver, BC, Canada., Simons E; Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Department of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada., Subbarao P; Department of Pediatrics and Physiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada., Scott JA; Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada., Wishart DS; Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada., Kozyrskyj AL; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. kozyrsky@ualberta.ca.
Jazyk: angličtina
Zdroj: International journal of obesity (2005) [Int J Obes (Lond)] 2022 Sep; Vol. 46 (9), pp. 1712-1719. Date of Electronic Publication: 2022 Jul 15.
DOI: 10.1038/s41366-022-01183-3
Abstrakt: Background/objectives: Differences in gut microbiota, metabolites and immune markers have been observed between individuals with and without obesity. Our study determined the temporal association between infant fecal gut metabolites, sIgA and body mass index (BMI) z score of preschool children, independent of pre/postnatal factors.
Subjects/methods: The study includes a subset of 647 infants from the CHILD Cohort Study (recruited between January 1, 2009, and December 31, 2012). Fecal metabolites and sIgA were measured at 3-4 months of age, and age and sex adjusted BMI z scores at 1 and 3 years of age. Associations between the metabolites, IgA, and child BMI z scores at age 1 and 3 years were tested using linear regression adjusted for pre/postnatal factors (breastfeeding, birthweight-for-gestational age, birthmode and IAP, solid food introduction).
Results: Mean BMI z score for all infants was 0.34 (SD 1.16) at 1 year (N = 647) and 0.71 (SD 1.06) at 3 years (N = 573). High fecal formate in infancy was associated with a significantly lower BMI z score (adjusted mean difference -0.23 (95% CI -0.42, -0.04)) and high butyrate was associated with a higher BMI z score (adjusted mean difference 0.21 (95% CI 0.01, 0.41)) at age 3 years only. The influence of formate and butyrate on BMI z score at age 3 were seen only in those that were not exclusively breastfed at stool sample collection (adjusted mean difference for high formate/EBF- group: -0.33 (95%CI -0.55, -0.10) and 0.25 (95% CI 0.02, 0.47) for high butyrate/EBF- group). No associations were seen between sIgA and BMI z score at age 1 or 3 years in adjusted regression models.
Conclusion and Relevance: Differences in fecal metabolite levels in early infancy were associated with childhood BMI. This study identifies an important area of future research in understanding the pathogenesis of obesity.
(© 2022. The Author(s), under exclusive licence to Springer Nature Limited.)
Databáze: MEDLINE
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