Assessing changes in nicotine consumption over two years in a population of Hanoi by wastewater analysis with benchmarking biomarkers.
Autor: | Thanh BX; Department of Public Health, University of Medicine and Pharmacy, Ho Chi Minh, Viet Nam., Vu GT; National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, QLD 4072, Australia., Hue TTT; Department of Pharmacology, National Institute of Drug Quality Control, Hanoi, Viet Nam; Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, Viet Nam., Zheng Q; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia., Chan G; National Centre for Youth Substance Use Research, The University of Queensland, Brisbane, QLD 4072, Australia., Anh NTK; Department of Analytical Chemistry and Toxicology, Hanoi University of Pharmacy, Viet Nam. Electronic address: anhntk@hup.edu.vn., Thai PK; Queensland Alliance for Environmental Health Sciences (QAEHS), The University of Queensland, 20 Cornwall Street, Woolloongabba, Queensland 4102, Australia. |
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Jazyk: | angličtina |
Zdroj: | The Science of the total environment [Sci Total Environ] 2022 Nov 10; Vol. 846, pp. 157310. Date of Electronic Publication: 2022 Jul 14. |
DOI: | 10.1016/j.scitotenv.2022.157310 |
Abstrakt: | Monitoring the actual change in consumption of nicotine (a proxy for smoking) in the population is essential for formulating tobacco control policies. In recent years, wastewater-based epidemiology (WBE) has been applied as an alternative method to estimate changes in consumption of tobacco and other substances in different communities around the world, with high potential to be used in resource-scarce settings. This study aimed to conduct a WBE analysis in Hanoi, Vietnam, a lower-middle-income-country setting known for high smoking prevalence. Wastewater samples were collected at two sites along a sewage canal in Hanoi during three periods: Period 1 (September 2018), Period 2 (December 2018-January 2019), and Period 3 (December 2019-January 2020). Concentrations of cotinine, 3-hydroxycotinine, and nicotine ranged from 0.73 μg/L to 3.83 μg/L, from 1.09 μg/L to 5.07 μg/L, and from 0.97 μg/L to 9.90 μg/L, respectively. The average mass load of cotinine estimated for our samples was 0.45 ± 0.09 mg/day/person, which corresponds to an estimated daily nicotine consumption of 1.28 ± 0.25 mg/day/person. No weekly trend was detected over the three monitoring periods. We found the amount of nicotine consumption in Period 1 to be significantly lower than in Period 2 and Period 3. Our WBE estimates of smoking prevalence were slightly lower than the survey data. The analysis of benchmarking biomarkers confirmed that cotinine was stable in the samples similar to acesulfame, while paracetamol degraded along the sewer canal. Further refinement of the WBE approach may be required to improve the accuracy of analyzing tobacco consumption in the poor sewage infrastructure setting of Vietnam. Competing Interests: Declaration of competing interest Authors declare no competing interests. (Copyright © 2022 Elsevier B.V. All rights reserved.) |
Databáze: | MEDLINE |
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