Low Stroke Risk in Children With Sickle Cell Disease in French Guiana: A Retrospective Cohort Study.

Autor:	Gargot J; Service de Pédiatrie, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana., Parriault MC; CIC INSERM 1424, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana., Adenis A; CIC INSERM 1424, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana., Clouzeau J; Service de Pédiatrie, Centre Hospitalier de l'Ouest-Guyanais «Franck Joly», Saint-Laurent-du-Maroni, French Guiana., Dinh Van KA; Département d'Information Médical, Centre Hospitalier de Kourou, Kourou, French Guiana., Ntab B; Département d'Information Médicale, Centre Hospitalier de l'Ouest-Guyanais «Franck Joly», Saint-Laurent-du-Maroni, French Guiana., Defo A; Service de Pédiatrie, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana., Nacher M; CIC INSERM 1424, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana., Elenga N; Service de Pédiatrie, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2022 Jun 28; Vol. 9, pp. 851918. Date of Electronic Publication: 2022 Jun 28 (Print Publication: 2022).
DOI:	10.3389/fmed.2022.851918
Abstrakt:	One in every 227 babies born in French Guiana has sickle cell disease, which represents the greatest incidence in France. This study aimed to determine the incidence of stroke in children with sickle cell disease and its associated risk factors. This retrospective cohort study included all children with sickle cell disease diagnosed in the neonatal period who were born in French Guiana between 01/01/1992 and 12/31/2002. Of a total of 218 records, 122 patients were included. There were 70 HbSS/Sβ0 (58%), 40 HbSC (33%), and 11 Sβ + thalassemia (9%). The number of emergency admissions was significantly different between genotypes, with a higher number in SS/Sβ0 children ( p = 0.004). There were significantly more acute chest syndromes ( p = 0.006) and more elevated Lactate Dehydrogenase in SS/Sβ0 patients ( p = 0.003). Three of these patients had ischemic strokes at a mean age of 6.9 years, and one had a hemorrhagic stroke at the age of 9,2 years. The incidence rate of ischemic stroke for SS/Sβ0 children was 3.1 (95% CI: 1.0-9.7) per 1,000 patient-years, and the clinically apparent stroke risk by the age of 15 years and 3 months was 6,4%. The incidence of hemorrhagic stroke was 1.1 (95% CI: 0.1-7.4) per 1,000 patients-years. No patient with SC or Sβ + thalassemia genotypes experienced any stroke. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2022 Gargot, Parriault, Adenis, Clouzeau, Dinh Van, Ntab, Defo, Nacher and Elenga.)
Databáze:	MEDLINE
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