Microplastics detected in cirrhotic liver tissue.

Autor:	Horvatits T; I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Electronic address: t.horvatits@uke.de., Tamminga M; Center for Earth System Research and Sustainability (CEN), University of Hamburg, Hamburg, Germany., Liu B; I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Sebode M; I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Carambia A; I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Fischer L; Department of Transplant Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Püschel K; Institute of Legal Medicine, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany., Huber S; I. Department of Medicine, Gastroenterology and Hepatology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany., Fischer EK; Center for Earth System Research and Sustainability (CEN), University of Hamburg, Hamburg, Germany. Electronic address: elke.fischer@uni-hamburg.de.
Jazyk:	angličtina
Zdroj:	EBioMedicine [EBioMedicine] 2022 Aug; Vol. 82, pp. 104147. Date of Electronic Publication: 2022 Jul 11.
DOI:	10.1016/j.ebiom.2022.104147
Abstrakt:	Background: The contamination of ecosystem compartments by microplastics (MPs) is an ubiquitous problem. MPs have been observed in mice tissues, and recently in human blood, stool and placenta. However, two aspects remain unclear: whether MPs accumulate in peripheral organs, specifically in the liver, and if liver cirrhosis favours this process. We aimed to examine human liver tissue samples to determine whether MPs accumulate in the liver. Methods: This proof-of-concept case series, conducted in Germany, Europe, analyzed tissue samples of 6 patients with liver cirrhosis and 5 individuals without underlying liver disease. A total of 17 samples (11 liver, 3 kidney and 3 spleen samples) were analyzed according to the final protocol. A reliable method for detection of MP particles from 4 to 30 µm in human tissue was developed. Chemical digestion of tissue samples, staining with Nile red, subsequent fluorescent microscopy and Raman spectroscopy were performed. Morphology, size and composition of MP polymers were assessed. Findings: Considering the limit of detection, all liver, kidney and spleen samples from patients without underlying liver disease tested negative for MPs. In contrast, MP concentrations in cirrhotic liver tissues tested positive and showed significantly higher concentrations compared to liver samples of individuals without underlying liver disease. Six different microplastic polymers ranging from 4 to 30 µm in size were detected. Interpretation: This proof-of-concept case series assessed the presence of MPs in human liver tissue and found six different MP polymers in the liver of individuals with liver cirrhosis, but not in those without underlying liver disease. Future studies are needed to evaluate whether hepatic MP accumulation represents a potential cause in the pathogenesis of fibrosis, or a consequence of cirrhosis and portal hypertension. Funding: No funding was received for conducting this investigator driven study. Competing Interests: Declaration of interests All authors declare that they have no conflict of interests regarding this manuscript. (Copyright © 2022 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze:	MEDLINE
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