Adaptation of the infant gut microbiome during the complementary feeding transition.

Autor: McKeen S; Riddet Institute, Massey University, Palmerston North, New Zealand.; School of Food and Advanced Technology, Massey University, Palmerston North, New Zealand.; AgResearch Ltd, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand., Roy NC; Riddet Institute, Massey University, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand.; Department of Human Nutrition, University of Otago, Dunedin, New Zealand., Mullaney JA; Riddet Institute, Massey University, Palmerston North, New Zealand.; AgResearch Ltd, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand., Eriksen H; High-Value Nutrition National Science Challenge, Auckland, New Zealand.; Department of Nutrition and Dietetics, The University of Auckland, Auckland, New Zealand., Lovell A; High-Value Nutrition National Science Challenge, Auckland, New Zealand.; Department of Nutrition and Dietetics, The University of Auckland, Auckland, New Zealand., Kussman M; German Entrepreneurship, Cambridge, Massachusetts, United States of America., Young W; Riddet Institute, Massey University, Palmerston North, New Zealand.; AgResearch Ltd, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand., Fraser K; Riddet Institute, Massey University, Palmerston North, New Zealand.; AgResearch Ltd, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand., Wall CR; High-Value Nutrition National Science Challenge, Auckland, New Zealand.; Department of Nutrition and Dietetics, The University of Auckland, Auckland, New Zealand., McNabb WC; Riddet Institute, Massey University, Palmerston North, New Zealand.; High-Value Nutrition National Science Challenge, Auckland, New Zealand.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2022 Jul 14; Vol. 17 (7), pp. e0270213. Date of Electronic Publication: 2022 Jul 14 (Print Publication: 2022).
DOI: 10.1371/journal.pone.0270213
Abstrakt: The infant gut microbiome progresses in composition and function during the introduction of solid foods throughout the first year of life. The purpose of this study was to characterize changes in healthy infant gut microbiome composition, metagenomic functional capacity, and associated metabolites over the course of the complementary feeding period. Fecal samples were obtained at three 'snapshot' timepoints from infants participating in the 'Nourish to Flourish' pilot study: before the introduction of solid foods at approximately 4 months of age, after introducing solid foods at 9 months of age, and after continued diet diversification at 12 months of age. KEGG and taxonomy assignments were correlated with LC-MS metabolomic profiles to identify patterns of co-abundance. The composition of the microbiome diversified during the first year of life, while the functional capacity present in the gut microbiome remained stable. The introduction of solid foods between 4 and 9 months of age corresponded to a larger magnitude of change in relative abundance of sequences assigned to KEGG pathways and taxonomic assignments, as well as to stronger correlations with metabolites, compared to the magnitude of changes and number of correlations seen during continued diet diversification between 9 and 12 months of age. Changes in aqueous fecal metabolites were more strongly correlated with KEGG pathway assignments, while changes in lipid metabolites associated with taxonomic assignments, particularly between 9 and 12 months of age. This study establishes trends in microbiome composition and functional capacity occurring during the complementary feeding period and identifies potential metabolite targets for future investigations.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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