Advances towards Cell-Specific Gene Transfection: A Small-Molecule Approach Allows Order-of-Magnitude Selectivity.

Autor: Dirksmeyer T; Institute of Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany., Stahl P; Institute of Biology, University of Duisburg-Essen, 45117, Essen, Germany., Vallet C; Institute of Biology, University of Duisburg-Essen, 45117, Essen, Germany., Knauer S; Institute of Biology, University of Duisburg-Essen, 45117, Essen, Germany., Giese M; Institute of Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany., Schmuck C; Institute of Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany., Hirschhäuser C; Institute of Organic Chemistry, University of Duisburg-Essen, 45117, Essen, Germany.
Jazyk: angličtina
Zdroj: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2022 Aug 01; Vol. 28 (43), pp. e202202024. Date of Electronic Publication: 2022 Jul 14.
DOI: 10.1002/chem.202202024
Abstrakt: Invited for the cover of this issue are Christoph Hirschhäuser and his colleagues from the University of Duisburg-Essen. The image depicts a biotin-labelled transfection vector selectively channelling DNA into a cancer cell. The QR code on the label will lead you to a video abstract (https://youtu.be/OgXfBPZTKGA). Read the full text of the article at 10.1002/chem.202104618.
(© 2022 Wiley-VCH GmbH.)
Databáze: MEDLINE
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