Resveratrol supplementation efficiently improves endothelial health: A systematic review and meta-analysis of randomized controlled trials.

Autor: Mohammadipoor N; Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran., Shafiee F; Nutrition Research Center, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran., Rostami A; Department of Internal Medicine, Faculty of General Medicine, Yerevan State Medical University after Mkhitar Heratsi, Yerevan, Armenia., Kahrizi MS; Student Research Committee, Alborz University of Medical Sciences, Karaj, Iran., Soleimanpour H; Department of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran., Ghodsi M; Assistant Professor of Cardiovascular Surgery, Department of Surgery, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran., Ansari MJ; Department of Pharmaceutics, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia., Bokov DO; Institute of Pharmacy, Sechenov First Moscow State Medical University, Moscow, Russian Federation.; Laboratory of Food Chemistry, Federal Research Center of Nutrition, Biotechnology and Food Safety, Moscow, Russian Federation., Jannat B; Halal Research Center of IRI, Food and Drug Administration, Ministry of Health and Medical Education, Tehran, Iran., Mosharkesh E; Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran., Pour Abbasi MS; Assistant Professor of Cardiovascular Surgery, Kashan University of Medical Sciences, Kashan, Iran.
Jazyk: angličtina
Zdroj: Phytotherapy research : PTR [Phytother Res] 2022 Sep; Vol. 36 (9), pp. 3529-3539. Date of Electronic Publication: 2022 Jul 14.
DOI: 10.1002/ptr.7562
Abstrakt: We perform a systematic review and meta-analysis of randomized controlled trials (RCTs) to quantify the effect of resveratrol supplementation on endothelial function. A comprehensive search was performed in electronic databases including PubMed, Scopus, Web of Science, and Cochrane Library up to February 2021 with no limitation in time and language. A meta-analysis of eligible studies was performed using a random-effects model to estimate the pooled effect size of flow-mediated dilation (FMD), intracellular adhesion molecule-1 (ICAM-1), vascular adhesion molecule-1 (VCAM-1), fibrinogen, and plasminogen activator inhibitor-1 (PAI-1). In total, 21 arms from 17 studies were included. The meta-analysis results showed that resveratrol significantly change the concentrations of FMD (WMD: 1.43%; 95% CI: 0.98 to 1.88, p < .001) and ICAM-1 (WMD: -7.09 ng/ml, 95% CI: -7.45 to -6.73, p < .001). However, VCAM-1, fibrinogen, and PAI-1 did not change significantly after resveratrol supplementation. In conclusion, the results of this study suggest that resveratrol supplementation can improve endothelial function which could be important, especially in patients with cardiovascular diseases.
(© 2022 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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