Zinc, Magnesium, and Copper Levels in Patients with Sickle Cell Disease: A Systematic Review and Meta-analysis.

Autor: Elkhidir IH; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Ali SS; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Ali WK; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Madani HR; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Basheir RA; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Altayeb RM; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Shazali RHS; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Fadlelmoula S; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Eltayeb WM; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Omar ZI; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Elnil M; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan., Mohamed SOO; Department of Pathology, Faculty of Medicine, University of Khartoum, Khartoum, Sudan.
Jazyk: angličtina
Zdroj: Avicenna journal of medicine [Avicenna J Med] 2022 Jul 02; Vol. 12 (2), pp. 45-53. Date of Electronic Publication: 2022 Jul 02 (Print Publication: 2022).
DOI: 10.1055/s-0042-1749612
Abstrakt: Background  Sickle cell disease (SCD) is associated with oxidative stress due to an imbalance between production and elimination of the reactive oxygen species. It has been reported that SCD patients are at risk of multiple micronutrients' deficiencies, including several trace elements involved in the antioxidation mechanisms. We aimed to assess the status of these micronutrients in SCD patients. Methods  This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. The databases of MedLine, Embase, and PsycInfo were used for the systematic search from time the databases existed until April 2021. A total of 36 studies fulfilled the eligibility criteria. We calculated the pooled standardized mean difference (SMD) of serum zinc, magnesium, or copper levels among patients with SCD and their healthy controls. Results  SCD patients had significantly lower zinc (SMD = -1.27 [95% CI: 1.67-0.87, p 0.001]) and magnesium levels (SMD = -0.53 [95% CI: 1.0-0.06, p 0.026] than their controls. Copper level was found to be significantly higher in SCD patients, with SMD = 0.68 (95% CI: 0.05-1.32, p 0.004). Conclusion  This review showed that SCD patients may potentially prompt to have lower zinc and magnesium levels and higher copper levels compared with those without the disease. Future research need to be directed to investigate clinical outcome of nutritional difficiencies in patients with SCD, as well as the possibility of implementing nutritional supplement programs which may help minimizing the harmful effects of the disease on human body.
Competing Interests: Conflict of Interest None declared.
(Syrian American Medical Society. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ).)
Databáze: MEDLINE
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