Screening of subclinical P300 event-related potentials changes in childhood acute lymphoblastic leukemia survivors.

Autor: Kroczka S; Department of Child Neurology, Jagiellonian University, Medical College, 30-663 Krakow, Poland.; Department of Child Neurology, University Children's Hospital, 30-663 Krakow, Poland., Kwiecinska K; Department of Pediatric Oncology and Hematology, Jagiellonian University, Medical College, 30-663 Krakow, Poland.; Department of Oncology and Hematology, University Children's Hospital, 30-663 Krakow, Poland., Gergont A; Department of Child Neurology, Jagiellonian University, Medical College, 30-663 Krakow, Poland.; Department of Child Neurology, University Children's Hospital, 30-663 Krakow, Poland., Grela A; Department of Child Neurology, University Children's Hospital, 30-663 Krakow, Poland., Gorowska O; Department of Child Neurology, University Children's Hospital, 30-663 Krakow, Poland., Skoczen S; Department of Pediatric Oncology and Hematology, Jagiellonian University, Medical College, 30-663 Krakow, Poland.; Department of Oncology and Hematology, University Children's Hospital, 30-663 Krakow, Poland.
Jazyk: angličtina
Zdroj: Molecular and clinical oncology [Mol Clin Oncol] 2022 Jun 14; Vol. 17 (2), pp. 125. Date of Electronic Publication: 2022 Jun 14 (Print Publication: 2022).
DOI: 10.3892/mco.2022.2558
Abstrakt: Modern treatment of childhood acute lymphoblastic leukemia (ALL) has resulted in a high cure rate; however, it can cause central nervous system toxicity. In the present study, a group of 136 ALL survivors were screened for changes in P300. Therapy was conducted according to a modified New York (NY) protocol (30 patients) and two subsequent revisions of a modified Berlin-Frankfurt-Münster (BFM) protocol (32 and 74 patients). The control group consisted of 58 patients. The survivors had significantly prolonged mean latency of P300 (331.31±28.71 vs. 298.14±38.76 msec, P<0.001) and reaction time (439.51±119.86 vs. 380.11±79.94 msec, P=0.002) compared with in the control group. Abnormalities in the endogenous evoked potentials were observed in 36 patients (26.5%). The mean latency time was significantly longer in the treatment groups compared with in the control group (NY: 329.13±28.07 msec, P=0.001; pBFM: 332.97±23.97 msec, P<0.001; BFM95: 331.47±31.05 msec, P<0.001). The reaction time was equally prolonged in both groups. In comparisons between the studied groups and the control group the most significant prolongation was recorded in the NY group (461.8±140.3 vs. 380.1±78.04 msec, P=0.039). Significantly higher frequency of prolonged reaction time in non-irradiated patients that received BFM95 was also revealed (21.62 vs. 15.85%, P=0.007). In addition, radiotherapy significantly reduced the P300 wave amplitude (mean values: 10.395±5.727 vs. 12.739±6.508 mV, P=0.027). In conclusion, endogenous P300 event-related potentials may be a useful tool in screening of subclinical cognitive changes in ALL survivors.
Competing Interests: The authors declare that they have no competing interests.
(Copyright © 2020, Spandidos Publications.)
Databáze: MEDLINE
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