Is there a role of proinflammatory cytokines on degenerin-mediated cerebrovascular function in preeclampsia?

Autor: Nemeth Z; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.; Institute of Translational Medicine, Faculty of Medicine, Semmelweis University, Budapest, Hungary.; Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary., Granger JP; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA., Ryan MJ; Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina, USA., Drummond HA; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Jazyk: angličtina
Zdroj: Physiological reports [Physiol Rep] 2022 Jul; Vol. 10 (13), pp. e15376.
DOI: 10.14814/phy2.15376
Abstrakt: Preeclampsia (PE) is associated with adverse cerebrovascular effects during and following parturition including stroke, small vessel disease, and vascular dementia. A potential contributing factor to the cerebrovascular dysfunction is the loss of cerebral blood flow (CBF) autoregulation. Autoregulation is the maintenance of CBF to meet local demands with changes in perfusion pressure. When perfusion pressure rises, vasoconstriction of cerebral arteries and arterioles maintains flow and prevents the transfer of higher systemic pressure to downstream microvasculature. In the face of concurrent hypertension, loss of autoregulatory control exposes small delicate microvessels to injury from elevated systemic blood pressure. While placental ischemia is considered the initiating event in the preeclamptic cascade, the factor(s) mediating cerebrovascular dysfunction are poorly understood. Elevated plasma proinflammatory cytokines, such as tumor necrosis factor α (TNF-α) and interleukin-17 (IL-17), are potential mediators of autoregulatory loss. Impaired CBF responses to increases in systemic pressure are attributed to the impaired pressure-induced (myogenic) constriction of small cerebral arteries and arterioles in PE. Myogenic vasoconstriction is initiated by pressure-induced vascular smooth muscle cell (VSMC) stretch. Recent studies from our laboratory group indicate that proinflammatory cytokines impair the myogenic mechanism of CBF autoregulation via inhibition of vascular degenerin proteins, putative mediators of myogenic constriction in VSMCs. This brief review links studies showing the effect of proinflammatory cytokines on degenerin expression and CBF autoregulation to the pathological cerebral consequences of preeclampsia.
(© 2022 The Authors. Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society.)
Databáze: MEDLINE
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