Your height affects your health: genetic determinants and health-related outcomes in Taiwan.

Autor: Chiou JS; PhD Program for Health Science and Industry, College of Health Care, China Medical University, Taichung, Taiwan.; Department of Health Services Administration, China Medical University, Taichung, Taiwan., Cheng CF; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Liang WM; Department of Health Services Administration, China Medical University, Taichung, Taiwan., Chou CH; PhD Program for Health Science and Industry, College of Health Care, China Medical University, Taichung, Taiwan.; Department of Health Services Administration, China Medical University, Taichung, Taiwan., Wang CH; Department of Pediatrics, China Medical University Children's Hospital, Taichung, Taiwan.; School of Medicine, China Medical University, Taichung, Taiwan., Lin WD; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.; School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan., Chiu ML; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan.; School of Chinese Medicine, China Medical University, Taichung, Taiwan., Cheng WC; PhD Program for Cancer Biology and Drug Discovery, China Medical University and Academia Sinica, Taichung, Taiwan.; Research Center for Cancer Biology, China Medical University, Taichung, Taiwan., Lin CW; PhD Program for Health Science and Industry, College of Health Care, China Medical University, Taichung, Taiwan.; Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung, Taiwan., Lin TH; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Liao CC; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Huang SM; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan., Tsai CH; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan., Lin YJ; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. yjlin.kath@gmail.com.; School of Chinese Medicine, China Medical University, Taichung, Taiwan. yjlin.kath@gmail.com., Tsai FJ; Big Data Center and Genetic Center, Department of Medical Research, China Medical University Hospital, Taichung, Taiwan. d0704@mail.cmuh.org.tw.; Department of Pediatrics, China Medical University Children's Hospital, Taichung, Taiwan. d0704@mail.cmuh.org.tw.; School of Chinese Medicine, China Medical University, Taichung, Taiwan. d0704@mail.cmuh.org.tw.; Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan. d0704@mail.cmuh.org.tw.
Jazyk: angličtina
Zdroj: BMC medicine [BMC Med] 2022 Jul 13; Vol. 20 (1), pp. 250. Date of Electronic Publication: 2022 Jul 13.
DOI: 10.1186/s12916-022-02450-w
Abstrakt: Background: Height is an important anthropometric measurement and is associated with many health-related outcomes. Genome-wide association studies (GWASs) have identified hundreds of genetic loci associated with height, mainly in individuals of European ancestry.
Methods: We performed genome-wide association analyses and replicated previously reported GWAS-determined single nucleotide polymorphisms (SNPs) in the Taiwanese Han population (Taiwan Biobank; n = 67,452). A genetic instrument composed of 251 SNPs was selected from our GWAS, based on height and replication results as the best-fit polygenic risk score (PRS), in accordance with the clumping and p-value threshold method. We also examined the association between genetically determined height (PRS 251 ) and measured height (phenotype). We performed observational (phenotype) and genetic PRS 251 association analyses of height and health-related outcomes.
Results: GWAS identified 6843 SNPs in 89 genomic regions with genome-wide significance, including 18 novel loci. These were the most strongly associated genetic loci (EFEMP1, DIS3L2, ZBTB38, LCORL, HMGA1, CS, and GDF5) previously reported to play a role in height. There was a positive association between PRS 251 and measured height (p < 0.001). Of the 14 traits and 49 diseases analyzed, we observed significant associations of measured and genetically determined height with only eight traits (p < 0.05/[14 + 49]). Height was positively associated with body weight, waist circumference, and hip circumference but negatively associated with body mass index, waist-hip ratio, body fat, total cholesterol, and low-density lipoprotein cholesterol (p < 0.05/[14 + 49]).
Conclusions: This study contributes to the understanding of the genetic features of height and health-related outcomes in individuals of Han Chinese ancestry in Taiwan.
(© 2022. The Author(s).)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje