The global impact of COVID-19 pandemic on the incidence of pediatric new-onset type 1 diabetes and ketoacidosis: A systematic review and meta-analysis.

Autor: Rahmati M; Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran., Keshvari M; Department of Physical Education and Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khoramabad, Iran., Mirnasuri S; Department of Pediatrics, Shahid Baghaei Hospital, Ahvaz, Iran., Yon DK; Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, Republic of Korea., Lee SW; Department of Data Science, Sejong University College of Software Convergence, Seoul, Republic of Korea.; Sungkyunkwan University School of Medicine, Suwon, Republic of Korea., Il Shin J; Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea., Smith L; Centre for Health, Performance, and Wellbeing, Anglia Ruskin University, Cambridge, UK.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2022 Nov; Vol. 94 (11), pp. 5112-5127. Date of Electronic Publication: 2022 Jul 22.
DOI: 10.1002/jmv.27996
Abstrakt: Viral infections may increase the risk of developing type 1 diabetes (T1D), and recent reports suggest that Coronavirus Disease 2019 (COVID-19) might have increased the incidence of pediatric T1D and/or diabetic ketoacidosis (DKA). Therefore, this meta-analysis aims to estimate the risk of global pediatric new-onset T1D, DKA, and severe DKA before and after the COVID-19 pandemic. A systematic search of MEDLINE/PubMed, CINAHL, Scopus, and EMBASE was conducted for articles published up to March 2022. A random-effects meta-analysis was performed to compare the relative risk of T1D and DKA among pediatric patients with T1D between the COVID-19 pre-pandemic and pandemic periods. We also compared glucose and HbA1c values in children who were newly diagnosed with T1D before and after the COVID-19 pandemic. The global incidence rate of T1D in the 2019 period was 19.73 per 100 000 children and 32.39 per 100 000 in the 2020 period. Compared with pre-COVID-19 pandemic, the number of worldwide pediatric new-onset T1D, DKA, and severe DKA during the first year of the COVID-19 pandemic increased by 9.5%, 25%, and 19.5%, respectively. Compared with pre-COVID-19 pandemic levels, the median glucose, and HbA1c values in newly diagnosed T1D children after the COVID-19 pandemic increased by 6.43% and 6.42%, respectively. The COVID-19 pandemic has significantly increased the risk of global pediatric new-onset T1D, DKA, and severe DKA. Moreover, higher glucose and HbA1c values in newly diagnosed T1D children after the COVID-19 pandemic mandates targeted measures to raise public and physician awareness.
(© 2022 Wiley Periodicals LLC.)
Databáze: MEDLINE
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