Understanding the pathogenesis of occupational coal and silica dust-associated lung disease.

Autor:	Vanka KS; School of Biomedical Sciences and Pharmacy, The University of Newcastle/Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia.; Division of Pulmonary, Allergy, and Critical Care Medicine, Dept of Medicine, University of Pennsylvania, Philadelphia, PA, USA.; Lung Biology Institute, University of Pennsylvania, Philadelphia, PA, USA., Shukla S; Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW, Australia., Gomez HM; School of Biomedical Sciences and Pharmacy, The University of Newcastle/Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia., James C; School of Health Sciences, The University of Newcastle, Newcastle, NSW, Australia., Palanisami T; Global Innovative Centre for Advanced Nanomaterials, College of Engineering, Science and Environment (CERSE), The University of Newcastle, Newcastle, NSW, Australia., Williams K; Newcastle Institute for Energy and Resources (NIER), School of Engineering, The University of Newcastle, Newcastle, NSW, Australia., Chambers DC; School of Clinical Medicine, The University of Queensland, Brisbane, QLD, Australia.; Queensland Lung Transplant Program, The Prince Charles Hospital, Brisbane, QLD, Australia., Britton WJ; Centenary Institute, The University of Sydney, Sydney, NSW, Australia.; Dept of Clinical Immunology, Royal Prince Alfred Hospital, Sydney, NSW, Australia., Ilic D; Newcastle Institute for Energy and Resources (NIER), School of Engineering, The University of Newcastle, Newcastle, NSW, Australia., Hansbro PM; School of Biomedical Sciences and Pharmacy, The University of Newcastle/Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia.; Centre for Inflammation, Centenary Institute, Sydney, NSW, Australia.; School of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, NSW, Australia.; P.M. Hansbro and J.C. Horvat have equally contributed as senior authors., Horvat JC; School of Biomedical Sciences and Pharmacy, The University of Newcastle/Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, Newcastle, NSW, Australia jay.horvat@newcastle.edu.; P.M. Hansbro and J.C. Horvat have equally contributed as senior authors.
Jazyk:	angličtina
Zdroj:	European respiratory review : an official journal of the European Respiratory Society [Eur Respir Rev] 2022 Jul 12; Vol. 31 (165). Date of Electronic Publication: 2022 Jul 12 (Print Publication: 2022).
DOI:	10.1183/16000617.0250-2021
Abstrakt:	Workers in the mining and construction industries are at increased risk of respiratory and other diseases as a result of being exposed to harmful levels of airborne particulate matter (PM) for extended periods of time. While clear links have been established between PM exposure and the development of occupational lung disease, the mechanisms are still poorly understood. A greater understanding of how exposures to different levels and types of PM encountered in mining and construction workplaces affect pathophysiological processes in the airways and lungs and result in different forms of occupational lung disease is urgently required. Such information is needed to inform safe exposure limits and monitoring guidelines for different types of PM and development of biomarkers for earlier disease diagnosis. Suspended particles with a 50% cut-off aerodynamic diameter of 10 µm and 2.5 µm are considered biologically active owing to their ability to bypass the upper respiratory tract's defences and penetrate deep into the lung parenchyma, where they induce potentially irreversible damage, impair lung function and reduce the quality of life. Here we review the current understanding of occupational respiratory diseases, including coal worker pneumoconiosis and silicosis, and how PM exposure may affect pathophysiological responses in the airways and lungs. We also highlight the use of experimental models for better understanding these mechanisms of pathogenesis. We outline the urgency for revised dust control strategies, and the need for evidence-based identification of safe level exposures using clinical and experimental studies to better protect workers' health. Competing Interests: Conflict of interest: No conflict of interest. (Copyright ©The authors 2022.)
Databáze:	MEDLINE
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