Analysis of viral nucleic acids in duodenal biopsies from adult patients with celiac disease.

Autor:	Calabretto M; Department of Molecular Medicine, Sapienza University of Rome., Di Carlo D; Department of Molecular Medicine, Sapienza University of Rome.; Istituto Pasteur Italia-Cenci Bolognetti Foundation, Rome., Falasca F; Department of Molecular Medicine, Sapienza University of Rome.; Transfusion Medicine Unit, 'F. Veneziale' Hospital, Isernia., Mazzuti L; Department of Molecular Medicine, Sapienza University of Rome., Meacci A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Donato G; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Greco N; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Mezzatesta L; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Morrone A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy., Turriziani O; Department of Molecular Medicine, Sapienza University of Rome., Picarelli A; Department of Translational and Precision Medicine, Sapienza University of Rome, Rome, Italy.
Jazyk:	angličtina
Zdroj:	European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2022 Nov 01; Vol. 34 (11), pp. 1107-1110. Date of Electronic Publication: 2022 Jul 14.
DOI:	10.1097/MEG.0000000000002404
Abstrakt:	Objective: The purpose of this study was to investigate the presence of Adenovirus, Epstein-Barr virus (EBV), HHV-6 and cytomegalovirus (CMV) nucleic acids in the gastrointestinal biopsies from active CD patients. Methods: Gastrointestinal biopsies of 40 active CD patients and 40 non-CD patients were collected during the endoscopic investigation of gastrointestinal symptoms. Results: HHV-6B was found in 62.5% of CD patients and in 65% of non-CD individuals, whereas the prevalence of EBV-positive samples was 20 and 10%, respectively. Nucleic acids from HHV-6A, CMV and adenovirus were not detected in any group. Conclusion: These data suggest that these viruses may not play a role in the pathogenesis of acute CD, but they do not exclude the possibility that viruses can act as a trigger for the onset of celiac disease. (Copyright © 2022 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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